Computed Properties of C6H15ClN2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Peptide Heterocycle Conjugates: A Diverted Edman Degradation Protocol for the Synthesis of N-Terminal 2-Iminohydantoins. Author is Evindar, Ghotas; Batey, Robert A..
A modified Edman degradation procedure provides an effective means of introducing a heterocycle at the N-terminus of an α-amino acid amide or peptide. Reaction of a peptide with an isothiocyanate, followed by dehydrothiolative trapping of the intermediate thiourea, by intramol. cyclization of the weakly nucleophilic adjacent amide nitrogen, generates an iminohydantoin. A solution-phase parallel synthesis of iminohydantoins and a polymer-supported synthesis of dipeptide- and tripeptide-derived iminohydantoins were also achieved.
This compound(H-Leu-NH2.HCl)Computed Properties of C6H15ClN2O was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.