Electric Literature of 850222-40-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 850222-40-1, Name is (S)-3-(Dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one, SMILES is O=C(C1=CC=CC(OC)=C1)[C@@H](C)CN(C)C, belongs to chiral-catalyst compound. In a article, author is Feng, Jia, introduce new discover of the category.
Atropisomers are important organic frameworks in bioactive natural products, drugs as well as chiral catalysts. Meanwhile, silanols display unique properties compared to their alcohol analogs, however, the catalytic synthesis of atropisomers bearing silanol groups is challenging. Here, we show a rhodium-catalyzed torsional strain-promoted asymmetric ring-opening reaction for the synthesis of alpha-silyl biaryl atropisomers. The reaction features a dynamic kinetic resolution of C(Ar)-Si bond cleavage, whose stereochemistry was controlled by a phosphoramidite ligand derived from (S)-3-methyl-1-((2,4,6-triisopropylphenyl)sulfonyl)piperazine. This work is a demonstration of an aryl-Narasaka acylation, where the C(Ar)-Si bond cleavage is promoted by the torsional strain of alpha, alpha’-disubstituted silafluorene.
Electric Literature of 850222-40-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 850222-40-1 is helpful to your research.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare