Perseo, Giuseppe; Forino, Romualdo; Galantino, Mauro; Gioia, Bruno; Malatesta, Vincenzo; De Castiglione, Roberto published an article about the compound: H-Leu-NH2.HCl( cas:10466-61-2,SMILESS:N[C@@H](CC(C)C)C(N)=O.[H]Cl ).Related Products of 10466-61-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:10466-61-2) through the article.
During the hydrogenolytic removal of the benzyl (Bzl) ester from Boc-Asp(OBzl)-Ala-Phe-Ile-Gly-OEt (I, Boc = Me3CO2C) with either hydrogen gas or ammonium formate in the presence of palladium-on-charcoal as catalyst, variable amounts (5-30%) of an unexpected byproduct were obtained. The byproduct was identified as Boc-Asc-Ala-Phe-Ile-Gly-OEt (Asc = aminosuccinyl). The application of field desorption mass spectrometry as a diagnostic tool is reported. The study of this side reaction, carried out on I and two other dipeptide models, showed that: 1) palladium-on-charcoal may induced Asc formation; 2) the contemporary presence of the catalyst and a base (even in trace amounts) greatly increases the byproduct formation; 3) the side reaction is sequence and solvent dependent; 4) the Asc formation is completely prevented by adding a few equivalent of acetic or formic acid. Some mechanistic considerations are reported.
The article 《Side reactions in peptide synthesis. I. Formation of aminosuccinyl derivatives from aspartyl peptides: a known side reaction in unusual conditions》 also mentions many details about this compound(10466-61-2)Related Products of 10466-61-2, you can pay attention to it, because details determine success or failure