Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,14098-24-9
A mixture of 3a (1 mmol) and benzo[18]krown-6 (312 mg, 1 mmol) in trifluoroacetic acid (2 mL) was kept for 24 h at room temperature. The solvent was removed under reduced pressure. The residue was diluted in aqueous ethanol and neutralized with a triethylamine to pH = 7. The obtained solution was stayed for 3 days in an open vessel. The precipitated product was separated by filtration and washed three times with water (3 * 5 mL) and dried in vacuo at 120 C. Yellow crystals; Yield 50%; Mp 240-242 C. 1H NMR (400 MHz, DMSO-d6) delta 8.66 (s, 1H), 8.48 (dd, J = 8.0, 2.0 Hz, 1H), 8.23 (d, J = 2.0 Hz, 1H), 7.22 (d, J = 8.0 Hz, 1H), 4.24-4.20 (m, 4H), 3.86-3.80 (m, 4H), 3.67-3.62 (m, 4H), 3.62-3.60 (m, 4H), 3.55 (s, 4H). 13C NMR (101 MHz, DMSO-d6+CCl4) delta 154.58, 154.04, 153.99, 152.08, 148.14, 143.60, 129.32, 126.68, 124.18, 112.45, 69.91, 69.77, 69.69, 68.57, 68.49, 68.22. Anal. Calcd. For C21H25N7O6: C, 53.50; H,5.34; N, 20.80. Found: C, 53.42; H, 5.47; N, 20.73.
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Reference£º
Article; Gorbunov, Evgeny B.; Rusinov, Gennady L.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.; Charushin, Valery N.; Chupakhin, Oleg N.; Tetrahedron Letters; vol. 57; 21; (2016); p. 2303 – 2305;,
Chiral Catalysts
Chiral catalysts – SlideShare