Recommanded Product: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis of substituted 3-amino-4-cyano-1-oxo-1,2,5,10-tetrahydroazepino[3,4-b]indoles. Author is Troschutz, Reinhard; Hoffmann, Armin.
The preparation of 3-amino- and 3-(dialkylamino)-4-cyanoazepino[3,4-b]indoles bearing substituents on the aromatic nucleus and N-10 is outlined. Starting from suitably substituted Et 3-formylindole-2-carboxylates, condensation with malononitrile and subsequent sodium borohydride reduction yielded Et 3-(2,2-dicyanoethyl)indole-2-carboxylates, resp., which were cyclized in boiling alkoxides to 3-alkoxy-4-cyanoazepino[3,4-b]indoles, e.g., I (R = OMe). This sequence constitutes a novel and flexible route to functional azepino[3,4-b]indoles. Aminolysis of the alkoxy derivatives yielded the title compounds, e.g., I (R = NMe2), which exhibited little or no biol. activity in several tests.
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