With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.
Trans-lambda ,2-diaminocyclohexane (5.7Og, 50 mmol) is dissolved in water (10 ml_). ^-tartaric acid (3.75g, 25 mmol) is added incrementally to the solution while continuously stirring and once completely added to the solution, the mixture is heated to 900C. When all the tartaric acid is dissolved, glacial acetic acid (5 ml_, 85 mmol) is added dropwise while stirring. The mixture is heated for 1 hour at 900C whereafter it is cooled to room temperature. The resultant white J.-1 ,2-diaminocyclohexane~l.-tartrate is filtered and washed twice with cold water (5 nnL), 3 times with methanol (5 mL) and oven dried. The salt is recrystallized out of hot water and cooled overnight at 50C.The recrystallized ^-1 ,2-diaminocyclohexane-Wartrate (18.9g, 72.62 mmol) is added to 4 equivalents of sodium hydroxide (11.62g, 290.49 mmol) dissolved in water (100 mL). Once the amine has dissolved it is extracted 5 times with 100 mL portions of dichloromethane. The extracted dichloromethane portions are added together and dried with anhydrous sodium sulphate. Most of the solvent is removed by vacuum distillation. The last portion of solvent is removed in atmospheric pressure to avoid the amine from distilling under vacuum using an air condenser. Yield: 23% (overall).The optically pure amine was then applied to prepare optically pure Pt(fr”a/7s-M ,2-diaminocyclohexane)CI2 by a method described in lnorganica Chimica Acta (1985) 108 : pp 63-66 (the content of which is incorporated herein by reference), from pure K2PtCI4, 1121-22-8
The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PLATCO TECHNOLOGIES (PROPRIETARY) LIMITED; WO2006/24897; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare