With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.250285-32-6,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,as a common compound, the synthetic route is as follows.
IPr-HCI (82.04 mg, 0.193 mmol), [Pd(cin)(M-CI)]2 (50.0 mg, 0.096 mmol), a magnetic stir bar and acetone (0.8 mL) were charged into a vial . The mixture was stirred at 60 C for 1 h . The solvent was removed and the product was dried under vacuum . The product was obtained as a dark orange powder in a 99% ( 132 mg) yield . Single crystals were grown by vapour diffusion of hex- ane into a solution of the complex in DCM . XH IMMR (400 MHz, CDCh) : delta (ppm) = 9.19 (s, 1 H), 8.32 (d, J = 1.60 Hz, 2H), 7.56-7.52 (m, 2H), 7.46 (d, J = 7.44 Hz, 2H), 7.33 (d, J = 7.75 Hz, 4H), 7.21 (m, 3H), 5.66 (s, 1 H), 4.46 (s, 1 H), 3.83 (s, 1 H), 2.90 (s, 1 H), 2.48- 2.41 (m, 4H), 1.27 (d, J = 6.81 Hz, 12H), 1.19 (d, J = 6.76 Hz, 12H) . 13C {XH } NMR (100 MHz, CDCh): delta (ppm) = delta 144.9 (C), 136.7 (CH), 131.8 (C), 129.7 (C), 128.4 (CH), 127.7 (CH), 127.5 (CH), 124.5 (CH), 105.0 (C), 28.8 (CHs), 24.4 (CHs), 23.7 (CHs) . Elemental analysis: Expected : C 63.02, H 7.05 N 4.08 Found : C 62.92 H 7.14 N 4.15
250285-32-6, The synthetic route of 250285-32-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UMICORE AG & CO. KG; NOLAN, Steven P.; (47 pag.)WO2018/115029; (2018); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare