With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.602-09-5,[1,1′-Binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.
602-09-5, [ 1 , 1 ,-Binaphthalene]-2,2′-diol (30.0 g, 0. 1 05 mo I, 1 .0 eq. ) was placed in a flask and flushed with argon. Anhydrous toluene (300 m L ) was added, followed by trifluoromethanesulfonic acid (1 1.7 ml., 0.2 1 0 mo I, 2.0 eq. ). After further degassing, the mixture was re fluxed for 48 hours. After cool ing, the organic layer was extracted with water (500 m l. ), dried over gSO i, and reduced under vacuum until precipitation. Hexane (300 ml.) was then added, and the resulting suspension was stirred for 2h before being filtered off. This solid was dissolved in DC I, and filtered over silica (elution with hexane / DCM 2 : 1 ). The volume of the fraction obtained was reduced to ca. 50 m l., and the resulting crystals were filtered off, yielding the title compound.
The synthetic route of 602-09-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVALED GMBH; DENKER, Urlich; ZOeLLNER, Mike; GRAeF, Katja; SENKOVSKYY, Volodymyr; WALLIKEWITZ, Bodo; SCHOLZ, Johannes; FREY, Julien; (143 pag.)WO2016/180891; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare