D-Phenylalanine, cas is 673-06-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,673-06-3
The 10mmolD-phenylalanie dissolved in 50 ml tetrahydrofuran, ice water bath to 0 C left and right, add triethylamine 20mmol. Then the 15mmol (Boc)2O into to the above-mentioned solution. 0 C left and right, reaction 60 min, then room temperature reaction 15h, after the reaction. The reaction solution with ethyl acetate extraction 2-3 time, remove the upper layer, pH is adjusted with acid, then dichloromethane is used for extraction 2-3 time. Merging the lower organic phase, dried with anhydrous sodium sulfate, concentrated solvent, get intermediate 1
With the synthetic route has been constantly updated, we look forward to future research findings about D-Phenylalanine,belong chiral-catalyst compound
Reference£º
Patent; Zunyi Medical College; Yang, Jiaqiang; Yang, Juan; Ceng, Fakui; Li, Peng; (9 pag.)CN105503947; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare