With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.673-06-3,D-Phenylalanine,as a common compound, the synthetic route is as follows.
673-06-3, (R)-2-Amino-3-phenylpropionic acid (5.3 g, 32 mmol) was placed into a three- necked flask, and water (24 mL) was added. The flask was fitted with two addition funnels. 2N H2SO4 (18 mL) was placed in one addition funnel and 2N aqueous NaNO2 (18 mL) was placed in the other one. The reaction vessel was cooled to 0C, and the acid was added dropwise with stirring. After the initial amino acid was dissolved, dropwise addition of the NaNO2 solution started. Upon completion of the addition, the reaction was stirred at 0C for 3 hours and then allowed to stir at room temperature for 2 days. Then the reaction mixture was extracted several times with ethyl acetate. The combined organic layers were dried, filtered and concentrated under reduced pressure to give E51 (3.6 g, 68% yield) as a white solid.
The synthetic route of 673-06-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PHENOMIX CORPORATION; BETANCORT, Juan Manuel; HEPPERLE, Michael E.; CAMPBELL, David Alan; WINN, David T.; WO2010/33466; (2010); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare