Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 3082-64-2, Name is (R)-1-Phenylpropan-1-amine, molecular formula is C9H13N. In an article, author is Renio, Marcia R. R.,once mentioned of 3082-64-2, Name: (R)-1-Phenylpropan-1-amine.
The enantioselective Henry reaction is a very important and useful carbon-carbon bond forming reaction. The execution of this reaction requires the use of efficient chiral catalysts. In this work, in situ formed complexes of N-substituted dihydroxypyrrolidines, chiral ligands derived from L-tartaric acid and amines, were evaluated as catalysts in the enantioselective Henry reaction. The results showed that the nature of the N-substituent on the ligand significantly influences the outcome of the reaction. Best results were obtained using a Cu (II) complex of (3S,4S)-N-benzyl-3,4-dihydroxypyrrolidine, in the presence of DIPEA, for the reaction of aromatic aldehydes with nitromethane, at room temperature, originating products with er up to 92:8 (R:S) and conversions up to 96%. The interaction between the pyrrolidine ligand and the copper ion, in isopropanol, was followed by UV-vis spectrophotometry, showing a 1:1 stoichiometry and a binding constant of 4.4. The results obtained will contribute to the design and development of more efficient chiral catalysts for this type of reaction.
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Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare