6645-46-1, Name is (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride, molecular formula is C7H16ClNO3, Formula: C7H16ClNO3, belongs to chiral-catalyst compound, is a common compound. In a patnet, author is Hwu, Jih Ru, once mentioned the new application about 6645-46-1.
Production of chiral compounds by green processes like domino reactions is of importance to environmental protection and sustainable development. Nevertheless, finding an appropriate catalyst to control enantioselectivity with satisfaction is a major challenge. Here, we report the accomplishment of a newly developed domino reaction for synthesizing optically active 3-pyrrolines, a class of compounds with various biological properties. The reaction involves the use of (trimethylsilyl)aryl triflates, Schiff bases, and alkynes in the presence of a chiral catalyst (R)-(-)-1,1 ‘-binaphthyl-2,2 ‘-diyl hydrogenphosphate. The key features of this new reaction include the generation of a single product in very good yields (75-85%) with high stereo- and enantio-selectivity; the enantiomeric ratio reaches as high as 98.5 : 1.5. Moreover, it involves an aryne-induced domino reaction and an unusual 1,4-intramolecular proton transfer, which overwhelms the well-established 1,5-proton transfer.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 6645-46-1. The above is the message from the blog manager. Formula: C7H16ClNO3.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare