Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Wang, Mo, once mentioned the application of 6381-59-5, Name is Potassium sodium tartrate tetrahydrate, molecular formula is C4H12KNaO10, molecular weight is 282.22, MDL number is MFCD00150989, category is chiral-catalyst. Now introduce a scientific discovery about this category, Quality Control of Potassium sodium tartrate tetrahydrate.
The catalytic asymmetric synthesis of the anti-COVID-19 drug Remdesivir has been realized by the coupling of theP-racemic phosphoryl chloride with protected nucleoside GS441524. The chiral bicyclic imidazole catalyst used is crucial for the dynamic kinetic asymmetric transformation (DyKAT) to proceed smoothly with high reactivity and excellent stereoselectivity (96 % conv., 22:1S(P):R-P). Mechanistic studies showed that this DyKAT is a first-order visual kinetic reaction dependent on the catalyst concentration. The unique chiral bicyclic imidazole skeleton and carbamate substituent of the catalyst are both required for the racemization process, involving the phosphoryl chloride, and subsequent stereodiscriminating step. A 10 gram scale reaction was also conducted with comparably excellent results, showing its potential for industrial application.
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Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare