In an article, author is Dong, Guizhi, once mentioned the application of 6645-46-1, Application In Synthesis of (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride, Name is (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride, molecular formula is C7H16ClNO3, molecular weight is 197.66, MDL number is MFCD00066100, category is chiral-catalyst. Now introduce a scientific discovery about this category.
An unprecedented catalytic asymmetric allylation of isatins and isatin-derived ketimines is reported enabled by a gold and chiral organocatalyst cooperative catalysis strategy. This method offers expeditious access to chiral 2,5-disubsituted alkylideneoxazolines containing vicinal stereogenic centers, mainly in optically pure form, and which are otherwise impossible to access. Mechanistic evidence reveals the presence of an alkylgold intermediate, and an X-ray crystal structure of the allylgold species illuminates its unique stability and reactivity. An asymmetric formal hetero-ene reaction of this gold intermediate, involving a dearomatization process, is enabled with assistance of a quinine-derived squaramide catalyst. This novel discovery extends the synthetic applications of gold complexes and the versatility of gold catalysis.
If you are interested in 6645-46-1, you can contact me at any time and look forward to more communication. Application In Synthesis of (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare