Sep 2021 News Extended knowledge of (1R,2R)-N1,N1,N2,N2-Tetramethylcyclohexane-1,2-diamine

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Electric Literature of 53152-69-5, An article , which mentions 53152-69-5, molecular formula is C10H22N2. The compound – (1R,2R)-N1,N1,N2,N2-Tetramethylcyclohexane-1,2-diamine played an important role in people’s production and life.

The racemic alpha-phenylselanylalkyllithium compound 6 is monomeric in diethyl ether and forms diastereoisomeric complexes with a variety of chiral diamines.Diastereoisomer ratios were determined from 77Se NMR spectroscopy to lie around 60:40 for most examples, but reached 90:10 with N,N,N’,N’tetramethylcyclopentane-1,2-diamine (22).The complexation constants for the formation of the diastereoisomeric complexes 24a and 24b formed from 6 with the latter ligand were estimated by NMR titration to be > 800 dm3 mol-1 and > 90 dm3 mol-1.The diastereoisomeric complexes 24 epimerize at the lithium bearing stereocentre with a barrier of DeltaG(excit.) = 12.1 +/-0.3 kcal mol-1 at -4 deg C.As this epimerization process is not slower than the racemization of the uncomplexed alkyllithium compound 6, the complexes 24 equilibrate directly and do not have to dissociate into 6 in order to equilibrate.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 53152-69-5, help many people in the next few years., Electric Literature of 53152-69-5

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare