(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9
0.53 g (1.5 mmol) of compound 3a prepared in Preparation 8 was dissolved in 10 ml of dry toluene, 0.39 ml of thionyl chloride was added,Argon gas was heated at 60 ¡ã C for 1 hour and evaporated to dryness. 10 ml of anhydrous DCM was added,(S) -2-aminomethyl-1-ethylpyrrole 0.23g under ice-water bath, the reaction was stirred at room temperature for 8 hours and then diluted with 50ml DCM,The organic layer was washed with saturated aqueous sodium bicarbonate solution and saturated sodium chloride solution respectively for 3 times. The organic layer was dried over Na2SO4, filtered and evaporated to give a yellowish oil, which was separated by a medium pressure silica gel column.Mobile phase petroleum ether: ethyl acetate 3: 1, the product fractions were collected and evaporated to dryness to give a yellowish oil 0.593g, yield 85.2percent.
With the rapid development of chemical substances, we look forward to future research findings about (S)-(1-Ethylpyrrolidin-2-yl)methanamine
Reference£º
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare