D-Phenylalanine, cas is 673-06-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,673-06-3
In a 3 1 jacketed reactor equipped with mechanical stirring and thermometer, 48% HBr (1,224.6 g, 7.265 moles), demineralized water (450 ml) and toluene (504 ml) were charged at 15C under nitrogen flow. The mixture temperature was brought to 0C and (D)-phenylalanine (300 g, 1.816 moles) was added. The mixture was then cooled to inner -5C and, in 5 hours, a solution of sodium nitrite (162.9 g, 2.361 moles) in demineralized water (306 ml) was dropped therein, keeping the temperature between -4C and -6C. After 3 hours the reaction temperature was brought to 15C and the stirring was kept on for another hour, then the reaction mixture was left to stand for half of hour, the nitrogen flow was stopped and the phases were separated. The organic phase was added with toluene (800 g, 924 ml) and demineralized water (450 g). The mixture was stirred for 1 hour, left to stand for half of hour, and the phases separated. The organic one was concentrated to dryness under vacuum in thermostated bath at 50C. There were thus obtained 385.8 g (1.684 moles) of (R)-2-bromo-3-phenyl-propionic acid (yield: 92.7%).
With the rapid development of chemical substances, we look forward to future research findings about D-Phenylalanine
Reference£º
Patent; ZAMBON GROUP S.p.A.; EP1056707; (2004); B1;,
Chiral Catalysts
Chiral catalysts – SlideShare