D-Phenylalanine, cas is 673-06-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,673-06-3
General procedure: L-Phenylalanine (1.5 g, 9.08 mmol, 1eq.) was suspended in 30 mL of NaOH (0.39 g, 9.98 mmol, 1.1 eq.) solution and the reaction mixture was diluted with tert-butanol. To this, di-tert-butyl pyrocarbonate (2.63 mL, 10.89 mmol, 1.2 eq) was added drop-wise with constant stirring. Reaction mixture was stirred at room temperature for overnight. Next day the reaction mixture was extracted with pentane and the organic phase is extracted with saturated NaHCO3 solution (315 mL). The combined aqueous layer was acidified to pH 2 with 1N HCl solution. The acidified layer was extracted with ethyl acetate (3×25 mL) and washed with brine solution (2×15 mL). The organic layer was dried over anhydrous sodium sulphate and concentrated to give the product (2.1 g, 87.5 % yield)
673-06-3 is used more and more widely, we look forward to future research findings about D-Phenylalanine
Reference£º
Article; Kumar, Vikas; Krishna, K. Vijaya; Khanna, Shruti; Joshi, Khashti Ballabh; Tetrahedron; vol. 72; 35; (2016); p. 5369 – 5376;,
Chiral Catalysts
Chiral catalysts – SlideShare