(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9
(S)-ethyl 2-(2,6-(UfIuOrO-S-JOdOnJCOtJnOyI)-S-(Tl -ethylpyrrolidin-2-yl)methylamino)acrylateEthyl 2-(2,6-difluoro-5-iodonicotinoyl)-3-(dimethylamino)acrylate (Intermediate 37, 0.500 g, 1.10 mmol) was taken up THF (40 mL) and cooled to 0 0C for 10 min and then (S)-(I- ethylpyrrolidin-2-yl)methanamine (0.153 mL, 1.10 mmol) was added and stirred at room temperature for 2 min. The reaction mixture was quenched with sat NH4Cl diluted with EtOAc and separated, dried, and solvent removed. The residue was purified by a 0-5percent gradient on the ISCO of DCM/Methanol to give (S)-ethyl 2-(2,6-difluoro-5-iodonicotinoyl)-3- ((l-ethylpyrrolidin-2-yl)methylamino)acrylate (0.36Og, 67percent) as a red oil. MS (ES) (M+H)+: 494 for Ci8H22F2IN3O3
As the rapid development of chemical substances, we look forward to future research findings about 22795-99-9
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BIFULCO, Neil; CHOY, Allison, Laura; QUIROGA, Olga; SHERER, Brian; WO2010/136817; (2010); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare