Reference of N5,N5-Dimethylpyridine-2,5-diamine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: N5,N5-Dimethylpyridine-2,5-diamine, is researched, Molecular C7H11N3, CAS is 39856-52-5, about Structure-Activity Relationship of Imidazo[1,2-a]pyridines as Ligands for Detecting β-Amyloid Plaques in the Brain. Author is Zhuang, Zhi-Ping; Kung, Mei-Ping; Wilson, Alan; Lee, Chi-Wan; Ploessl, Karl; Hou, Catherine; Holtzman, David M.; Kung, Hank F..
A series of novel β-amyloid (Aβ) aggregate-specific ligands, e.g., 2-(4′-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine (I; IMPY), and its related derivatives were prepared An in vitro binding study with preformed Aβ aggregates showed that I and its bromo derivative competed with binding of 2-(4′-dimethylaminophenyl)-6-iodobenzothiazole, [125I]7(TZDM), a known ligand for Aβ aggregates, with high binding affinities (Ki = 15 and 10 nM, resp.). In vitro autoradiog. of brain sections of a transgenic mouse (Tg2576) with [125I]-I displayed high selective binding to amyloid-like structures, comparable to that observed by staining with thioflavin-S visualized under fluorescence. In vivo biodistribution after an i.v. injection of [125I]-I in normal mice showed a high initial brain uptake and fast washout, indicating a low background activity associated with this iodinated ligand. Taken together, the data suggests that [123I]-I may be useful for imaging Aβ aggregates in patients with Alzheimer’s disease.
This compound(N5,N5-Dimethylpyridine-2,5-diamine)Reference of N5,N5-Dimethylpyridine-2,5-diamine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.