A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 17455-13-9, Name is 1,4,7,10,13,16-Hexaoxacyclooctadecane, molecular formula is C12H24O6. In an article, author is Zhu, Minghui,once mentioned of 17455-13-9, Formula: C12H24O6.
Both syn- and anti-beta-amino alcohols are common structural motifs in natural products, drug molecules, chiral ligands and catalysts. However, the currently available methods for synthesizing these motifs are limited to generate only one diastereoisomer. Therefore, development of a unified method for stereoselective access to complementary diastereomers would be highly desirable. Herein, we report a method for dual-metal-catalyzed diastereodivergent coupling of alkoxyallenes with aldimine esters. By carefully selecting the two metals and appropriate chiral ligands, we could synthesize both syn- and anti-beta-amino alcohol motifs with high enantioselectivity and diastereoselectivity from the same set of starting materials. Furthermore, stereodivergent syntheses of all four stereoisomers of beta-amino alcohols could be achieved. We demonstrated the synthetic utility of this method by concisely synthesizing two beta-amino alcohol natural products, mycestericins F and G.
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Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare