250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Under air environment, a 25 mL single-necked round-bottom flask, equipped with a magnetic bar, was charged with LiCl (4 mmol 170 mg) and PdCl2 (2 mmol 354 mg), then 10 mL MeOH was added into the flask. The resultant mixture was then stirred at rt for 8 hours to generate LiPdCl4-MeOH solution. After that, a 50 mL double-necked round-bottom flask, equipped with a magnetic bar, was charged with NaOAc (2 mmol 164 mg) and acetophenone oxime 5. Then, the flask was sealed with a rubber septum, and LiPdCl4-MeOH solution (2 mmol) was injected through the septum. The mixture was allowed to stirred at rt for 3 days. After this time, the reaction mixture was filtrated, washed by MeOH, and then dried under vacuum to afford palladacycle dimmer without further purification. Under Nitrogen, to a Schlenk flask charged with KOtBu (1.3 mmol 146 mg), palladacycle complex (0.5 mmol 290 mg) and excess NHC?HCl (1.25 mmol 531 mg) was added dry THF distilled from sodium/benzophenone at room temperature. The resultant mixture was allowed to stirred at rt for 2 days. Extraction with ethyl acetate, dried over anhydrous Na2SO4. After concentrated, the residue was purified by flash column chromatography using hexane-EtOAc=5:1 as eluent to afford the desired N-heterocyclic carbene palladium complex 6.
As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.
Reference£º
Article; Shen, An; Ni, Chen; Cao, Yu-Cai; Zhou, Hui; Song, Gong-Hua; Ye, Xiao-Feng; Tetrahedron Letters; vol. 55; 21; (2014); p. 3278 – 3282;,
Chiral Catalysts
Chiral catalysts – SlideShare