Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 43142-76-3, is researched, SMILESS is O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC, Molecular C12H10ClNO3Journal, Article, Bioorganic & Medicinal Chemistry called Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5-6 fused rings as alternative S1 moieties, Author is Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu, the main research direction is cis diamino cyclohexane derivative factor Xa inhibitor structure.Synthetic Route of C12H10ClNO3.
A series of cis-1,2-diaminocyclohexane derivatives were synthesized with the aim of optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5-6 fused rings as alternative S1 moieties resulted in two compounds which demonstrated improved solubility and reduced food effect compared to the clin. candidate, compound A. Herein, we describe the synthesis and structure-activity relationship (SAR), together with the physicochem. properties and pharmacokinetic (PK) profiles of some prospective compounds
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