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Substituted phenethylsulfones and method of reducing TNFalpha levels
Phenethylsulfones substituted in the position alpha to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline group reduce the levels of TNFalpha in a mammal. Typical embodiments are 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-aminoisoindoline-1,3-dione and 2-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-methylsulfonylethyl]isoindoline-1,3-dione.
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Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare