Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 80657-57-4, Name is (S)-Methyl 3-hydroxy-2-methylpropanoate, SMILES is O=C(OC)[C@@H](C)CO, belongs to chiral-catalyst compound. In a document, author is Harada, Shingo, introduce the new discover, Category: chiral-catalyst.
Despite a growing body of studies on directing-group (DG)-assisted C-H activation strategies, efficient exploitation of the used DG remains underexplored. We developed a rhodium-catalyzed C-H functionalization of indoles at the C4 position using alpha,beta-unsaturated enones as versatile DGs. Combined experimental and theoretical analyses revealed that the C-H activation process was reversible and the course of Rh-carbene generation controlled the overall site-selectivity of the C-H functionalization. The introduced malonate unit and the used enone DG were cyclized in a further C-C bond forming process to assemble 3,4-fused tricyclic indoles in an asymmetric manner. Telescoping the two reaction sequences provided rapid entry into this densely functionalized indole architecture from readily available chemical feedstock.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 80657-57-4 is helpful to your research. Category: chiral-catalyst.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare