Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Stockhammer, Lotte, once mentioned the application of 57090-45-6, Name is (R)-(-)-3-Chloro-1,2-propanediol, molecular formula is C3H7ClO2, molecular weight is 110.5395, MDL number is MFCD00135169, category is chiral-catalyst. Now introduce a scientific discovery about this category, Recommanded Product: (R)-(-)-3-Chloro-1,2-propanediol.
We herein report an unprecedented strategy for the asymmetric alpha-chlorination of beta-keto esters with hypervalent iodine-based Cl-transfer reagents using simple Cinchona alkaloid catalysts. Our investigations support an alpha-chlorination mechanism where the Cinchona species serves as a nucleophilic catalyst by reacting with the chlorinating agent to generate a chiral electrophilic Cl-transfer reagent in situ. Using at least 20 mol-% of the alkaloid catalyst allows for good yields and enantioselectivities for a variety of different beta-keto esters under operationally simple conditions.
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Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare