Synthetic Route of C6H15ClN2O. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Peptide synthesis using carbamoylmethyl esters as acyl donors mediated by Bacillus amyloliquefaciens protease. Author is Miyazawa, Toshifumi; Shindo, Tadamichi; Murashima, Takashi; Yamada, Takashi.
Bacillus amyloliquefaciens protease-catalyzed peptide bond formation was investigated using the carbamoylmethyl (Cam) ester as the acyl donor. A series of N-protected L-amino acid Cam esters were coupled with an L-amino acid amide in acetonitrile in good to excellent yields. The superiority of the Cam ester for segment condensations was demonstrated in several 2 + 1 couplings. Furthermore, the couplings of racemic amino acid Cam esters as carboxyl components afforded the L-L-peptides in a highly diastereoselective manner.
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