With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.
A solution of thiazole-2-carboxaldehyde (2.00 g, 17.7 mmol) in N,N-dimethylformamide (4.0 mL) was swirled as trans-N,N’-1,2-diaminocyclohexane (1.05 mL, 8.74 mmol) was added, which resulted in slight warming. After three days at ambient temperature, yellowish crystals were collected by filtration, rinsed with N,N-dimethylformamide (10 mL, in portions) and water (10 mL, in portions), and dried in vacuo (trans-N,N’-bis(thiazol-2-ylmethylene)-1,2-diaminocyclohexane, 1.91 g). After three days, a second crop of yellowish crystals was likewise collected from the initial filtrate (trans-N,N’-bis(thiazol-2-ylmethylene)-1,2-diaminocyclohexane, 0.33 g, 84.3% total yield). 1H NMR (CDCl3, delta): 8.36 (d, J = 0.8, 2H, imine), 7.81 (d, J = 3.2, 2H, Thz), 7.31 (dd, J = 3.2, 0.8, 2H, Thz), 3.48 (m, 2H, NCH), 1.84 (m, 4H, cyclohexyl), 1.79 (m, 2H, cyclohexyl), 1.47 (m, 2H, cyclohexyl). 13C NMR (CDCl3, delta): 167.1 (Thz 2), 154.7 (Thz 4,5), 143.8 (Thz 4,5), 121.3 (imine), 73.1 (NCH), 32.4 (cyclohexyl), 24.1 (cyclohexyl). Anal. Calc. for C14H16N4S: C, 55.23; H, 5.30; N, 18.40. Found: C, 55.29; H, 5.55; N, 18.37%., 1121-22-8
As the paragraph descriping shows that 1121-22-8 is playing an increasingly important role.
Reference£º
Article; Bennov, Rachel R.; Berko, David A.; Burgess, Samantha A.; Dimeglio, John L.; Kalman, Steven E.; Ludlum, Jeffrey M.; Nash, Bradley W.; Palomaki, Peter K.B.; Perlow, Daniel B.; Rubin, Jacob A.; Saunders, Janet E.; Scarselletta, Sarah V.; Kastner, Margaret E.; Pike, Robert D.; Sabat, Michal; Keane, Joseph M.; Inorganica Chimica Acta; vol. 438; (2015); p. 64 – 75;,
Chiral Catalysts
Chiral catalysts – SlideShare