With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137848-28-3,(R)-2′-amino-[1,1′-binaphthalen]-2-ol,as a common compound, the synthetic route is as follows.
To a magnetically stirred solution of R-(+)-2-amino-1,1′-binaphthalen-2-ol (0.206 g, 0.722 mmol) in DMAC (15 mL) was slowly added a solution of terephthaloyl chloride (0.0733 g, 0.361 mmol) in DMAC (10mL). After the addition was complete, the reaction mixture was stirred at room temperature for 24h and then concentrated in vacuo to give a crude tan solid. The solid was dissolved in CHCl3 (300 mL) and washed with water (3¡Á100 mL) and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate and then concentrated in vacuo to furnish monomer 3RR (85% yield) as a light tan powder. mp: >250C (decomposition). 1H NMR (DMSO-d6, 500MHz) delta 9.74 (s, 2H), 8.83 (s, 2H), 8.15-8.18 (m, 2H), 8.03-8.07 (m, 2H), 7.97-8.02 (m, 4H), 7.91-7.95 (m, 2H), 7.43-7.48 (m, 2H), 7.37-7.41 (m, 2H), 7.24-7.33 (m, 4H), 7.09-7.17 (m, 8H), 6.86-6.90 (m, 2H); MS m/e: 701.24 ([M]H+). [alpha]D=(+)76 (c=0.130g/dL, THF)., 137848-28-3
As the paragraph descriping shows that 137848-28-3 is playing an increasingly important role.
Reference£º
Article; Lynch, Joseph G.; Jaycox, Gary D.; Polymer; vol. 55; 16; (2014); p. 3564 – 3572;,
Chiral Catalysts
Chiral catalysts – SlideShare