With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.
SIMes-HCI (100 mg, 0.292 mmol), [Pd(cin)(M-CI)]2 (62.9 mg, 0.122 mmol), a magnetic stir bar and acetone (1.2 mL) were charged into a vial or round bottom flask , followed by K2C03 (33.5 mg, 0.243 mmol). The mixture was stirred at 60 C for 5 h. The general work up procedure was then followed, affording the product as microcrystalline material in 80% (135 mg) yield. XH NMR (400 MHz, CDCh): delta (ppm) =67.12 (m, 3H), 7.06 (m, 2H), 6.96 (d, J = 11.19 Hz, 4H), 5.30 (s, 1 H), 5.12-5.04 (m, 1H), 4.27 (d, J = 12.96 Hz, 1H), 3.99 (m, 4H), 3.27 (d, J = 6.86 Hz, 1H), 2.44 (d, J = 15.24 Hz, 10H), 2.31 (s, 6H), 1.93 (m, 1H). 13C {XH} IMMR (100 MHz, CDCb): delta (ppm) = delta 210.9 (C, carbene), 138.0 (C), 137.8 (C), 136.3 (C), 135.7 (C), 129.1 (CH), 128.0 (CH), 127.5 (CH), 127.1 (CH), 126.4 (CH), 109.4 (CH), 92.1 (CH), 51.0 (CH2), 46.5 (CH2), 20.9 (CHs).Elemental analysis: Expected : C 66.76, H 7.72, N 4.21. Found : C 66.63, H 7.64, N 4.27.
As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.
Reference£º
Patent; UMICORE AG & CO. KG; NOLAN, Steven P.; (47 pag.)WO2018/115029; (2018); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare