With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.
In analogy to S. P. Nolan, Organometallics 1999, 18, 5416-5419, a suspension of 1.55 g (4.33 mmol) of 1,3-bis(2,4,6-trimethylphenyl)-imidazolium chloride (commercially available from Strem Chemicals Inc., D-77672 Kehl) and 2.70 ml (4.59 mmol) of potassium tert.-pentylate (1.7 M in toluene) was suspended in 20 ml hexane and heated at 50 C. for 10 min. 2.00 g (2.17 mmol) of [RuCl2(Pcy3)2(3-phenyl-indenylidene)] was added and the resulting red suspension stirred at 50 C. for 15 h. The reaction mixture was allowed to cool to r.t., the formed brown crystals were filtered off and washed with 40 ml pentane. The crystals were dissolved in 30 ml dichloromethane. 30 ml water was added and the organic layer was separated and dried over Na2SO4. The orange solution was evaporated to dryness and the isolated red crystals washed with 30 ml pentane and dried under vacuum to yield 2.05 g (81% yield) of the title compound. MS: 946.3 (M+). 31P-NMR (121 MHz, C6D6): 27.4 ppm. 1H-NMR (300 MHz, C6D6): 1.00-1.40 (m, 18H); 1.47-1.68 (m, 6H); 1.70-1.84 (m, 3H); 1.80 (s, 3H); 1.85-1.95 (m, 3H); 2.04 (s, 3H); 2.20 (s, 3H); 2.24 (s, 3H); 2.45-2.60 (m, 3H); 2.65 (s, 3H); 2.67 (s, 3H); 6.03 (s, 1H); 6.16 (s, 2H); 6.47 (s, 1H); 6.95 (s, 2H); 7.10-7.37 (m, 6H); 7.85 (s, 1H); 7.87-7.93 (m, 2H); 9.12 (d, 1H, J=6.8 Hz). Anal. calcd. for C54H67N2Cl2PRu: C, 68.48; H, 7.13; N, 2.96; Cl, 7.49. Found: C, 68.71; H, 7.11; N, 3.77; Cl, 7.37., 141556-45-8
As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.
Reference£º
Patent; Puentener, Kurt; Scalone, Michelangelo; US2006/241156; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare