As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is (1R,2S)-2-Amino-1,2-diphenylethanol, and cas is 23190-16-1, its synthesis route is as follows.,23190-16-1
A solution of HBTU in DMF (1 M, 0.048 ML) was added to a mixture of (R)- 3-benzo [b] THIOPHEN-3-YL-2-PHENYLMETHANESULPHONYLAMINO-PROPIONIC acid (Intermediate 1,15 mg. 0.04 MMOL) and (1 R, 2S)-(-)-2-AMINO-1, 2-DIPHENYLETHANOL (10.2 mg, 0.048 MMOL) in DMF (0.1 ML). The mixture was treated briefly in an ultrasonic bath to ensure complete solution of reagents and the solution was stored at room temperature for 3 days. Purification by preparative hplc (see Methods) gave the desired product, 7.3 mg (32%), HPLC/MS Rt 5.89 min, m/z 571.
With the complex challenges of chemical substances, we look forward to future research findings about 23190-16-1,belong chiral-catalyst compound
Reference£º
Patent; DE NOVO PHARMACEUTICALS LIMITED; WO2004/20402; (2004); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare