With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22795-99-9,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,as a common compound, the synthetic route is as follows.
22795-99-9, 0.53 g (1.5 mmol) of compound 3a prepared in Preparation 8 was dissolved in 10 ml of dry toluene, 0.39 ml of thionyl chloride was added,Argon gas was heated at 60 ¡ã C for 1 hour and evaporated to dryness. 10 ml of anhydrous DCM was added,(S) -2-aminomethyl-1-ethylpyrrole 0.23g under ice-water bath, the reaction was stirred at room temperature for 8 hours and then diluted with 50ml DCM,The organic layer was washed with saturated aqueous sodium bicarbonate solution and saturated sodium chloride solution respectively for 3 times. The organic layer was dried over Na2SO4, filtered and evaporated to give a yellowish oil, which was separated by a medium pressure silica gel column.Mobile phase petroleum ether: ethyl acetate 3: 1, the product fractions were collected and evaporated to dryness to give a yellowish oil 0.593g, yield 85.2percent.
As the paragraph descriping shows that 22795-99-9 is playing an increasingly important role.
Reference£º
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare