With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7181-87-5,1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide,as a common compound, the synthetic route is as follows.
The reagent and solvent shown below were placed in a 50 mL flask under nitrogen flow. F13: 274 mg (1.00 mmol) (purchased from Sigma-Aldrich) Dehydrated DMF: 10 ml.After the solution was degassed with nitrogen, 192 mg (4.00 mmol) of sodium hydride (60% oil dispersion) was added and stirred for 2 minutes. Thereafter, 112 mg (1.00 mmol) of potassium tert-butoxide was added, and the mixture was stirred at room temperature for 6 hours. After completion of the reaction, 30 ml of water degassed with nitrogen while stirring was gradually added to precipitate the desired product, and then the solvent was removed with a silane. After the addition of 20 ml of de-gassed water with nitrogen, the solvent was removed twice with distilled water, and 10 ml of hexane degassed with nitrogen was added, followed by dispersion washing using an ultrasonic washing machine , And was filtered through a membrane filter. It was confirmed that the filtrate partially deliquesced. Thereafter, drying was carried out at 50 C. under reduced pressure to obtain 116 mg (yield 40%) of Comparative Compound 3 as a black brown solid.
As the paragraph descriping shows that 7181-87-5 is playing an increasingly important role.
Reference£º
Patent; CANON INCORPORATED; MIYASHITA, HIROKAZU; NISHIDE, YOSUKE; KAMATANI, JUN; (41 pag.)JP2017/8011; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare