Recommanded Product: 43142-76-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Synthesis and properties of certain 5H-pyridazino[4,5-b]indoles. Author is El-Gendy, A.A.; Abou-Sier, Afaf H..
5H-Pyridazino[4,5-b]indoles [I; R = H, Me, benzyl] were obtained by heating Et 3-formylindole-2-carboxylates [II; R same as above; R1 = CHO, R2 = OEt] with hydrazine hydrate or by direct formylation of the corresponding 2-indolecarboxhydrazides II [R same as above; R1 = H, R2 = NHNH2] with dimethylformamide/phosphoryl chloride. The 4-chloro-5H-pyridazino[4,5-b]indoles [III; R same as above; R3 = Cl] were prepared by treatment of I with phosphoryl chloride. Reaction of compounds III [R same as above; R3 = Cl] with hydrazine hydrate yielded the 4-hydrazino-5H-pyridazino[4,5-b]indoles [III; R same as above; R3 = NHNH2]. The antihypertensive activity of compound [III; R = H, R3 = NHNH2] is under pharmacol. screening.
Different reactions of this compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate)Recommanded Product: 43142-76-3 require different conditions, so the reaction conditions are very important.