So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hasan, Fariza B.; Cohen, Saul G. researched the compound: 2-Chloroethyl acetate( cas:542-58-5 ).Recommanded Product: 542-58-5.They published the article 《Hydrolysis by acetylcholinesterase. Trimethyl and methyl subsites》 about this compound( cas:542-58-5 ) in Jerusalem Symposia on Quantum Chemistry and Biochemistry. Keywords: acetylcholinesterase active site. We’ll tell you more about this compound (cas:542-58-5).
A study was made of the kinetics of hydrolysis by acetylcholinesterase and by OH- of the acetate esters, RCH2CH2OCOMe, where R = (Me)3N+-, (Me)3C-, (Me)2NH+-, (Me)2CH-, MeNH2+-, MeCH2-, NH3+-, Me-, H-, HO-, MeO-, Cl-, Br-, NC-. Comparative values of the equilibrium binding constant, Ks, indicated that the pos. charge of the β-substituent, R, makes little if any contribution to substrate binding. The acylation rate constant, k2, and the enzymic reactivity, k2/Ks were normalized for the effects of β-substituents on the intrinsic reactivity to OH-. A linear relation was found between the log of the normalized enzymic reactivity and the apparent molal volume of the β-substituent. Cogent evidence was not found for a neg. charge in the anionic site, which is better considered a tri-Me site. Enzymic reactivity is determined predominantly by precision of fit of the β-substituent in the tri-Me site, the acetyl Me in its Me site, and the ester grouping at the serine OH.
There is still a lot of research devoted to this compound(SMILES：CC(OCCCl)=O)Recommanded Product: 542-58-5, and with the development of science, more effects of this compound(542-58-5) can be discovered.