Tag: 14098-24-9

A common heterocyclic compound, the chiral-catalyst compound, name is Benzo-18-crown 6-Ether,cas is 14098-24-9, mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

A mixture of 0.27 g OfMo(CO)6 (1.03 mmol), 0.12 g of KBr (1.00 mmol) and 0.31 g of benzo-18-crown-6-ether (1.00 mmol) was refluxed in 15 ml of freshly distilled THF for 2 hours. The yellow solution was filtered and a brown oil formed and started to separate. After decanting the oil, 40 ml of hexane were added and the schlenk was left at 0 0C to isolate a yellow solid. Extraction with CH2Cl2 afforded K[benzo-18-crown-6-ether][Mo(CO)5Br] as yellow needles (75% yield , 0.5 g).Analysis Calculated for BrC21H24KMo11: C, 37.80; H, 3.62. Found: C, 37.25; H5 3.83. IR (KBr pellet), cm4: 3069 (w), 2955 (m), 2941 (m), 2921 (m), 2067 (m), 1977 (w), 1932 (sh, s), 1914 (s), 1842 (s), 1834 (s), 1638 (br, w), 1596 (w), 1523 (w), 1505 (s), 1478 (w), 1457 (m), 1436 (w), 1382 (w), 1355 (m), 1343 (m), 1325 (m), 1286 (m), 1247 (s), 1214 (s), 1178 (br, sh5 w), 1166 (w), 1126 (m), 1116 (m), 1108 (m), 1097 (sh, w), 1083 (w), 1075 (w), 1055 (w), 961 (m), 952 (m), 935 (w), 922 (w), 908 (w), 882 (w), 860 (w), 848 (w), 833 (w), 806 (br, w), 782 (m), 737 (s), 598 (s), 542 (m), 507 (w), 463 (w). 1H NMR (CD2Cl2, 300 MHz): 7.00-6.90 (c, 4H, C6H4 crown ether), 4.22 + 3.95 + 3.77-3.42 (c, 1OH, aliphatic crown ether protons).

As the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

Reference£º
Patent; ALFAMA – INVESTIGACAO E DESENVOLVIMENTO DE PRODUTOS FARMACEUTICOS LDA.; WO2007/73225; (2007); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

14098-24-9, Benzo-18-crown 6-Ether is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A modification of the previously reported procedure23 was used. Commercially available Eaton’s reagent (ca. 8 ml that corresponds to 6.28 mmol of phosphorus(V) oxide) and acetic acid (0.20 ml, 3.45 mmol) were mixed at room temperature. Then naphtho-15-crown-5 ether (1 g, 3.14 mmol) was added. The reaction mixture was stirred at room temperature for ca. 6 h and then poured into water. The suspension was extracted with dichloromethane and the combined organic phases were washed with water. Removal of the dried (MgSO4) solvent gave a dark brown oil, which upon repeated extractions with hot heptane, afforded the product as an off-white solid (1.02 g, 90%), mp 126-129 C., 14098-24-9

The synthetic route of 14098-24-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Paramonov, Sergey V.; Lokshin, Vladimir; Smolentsev, Artem B.; Glebov, Evgeni M.; Korolev, Valeri V.; Basok, Stepan S.; Lysenko, Konstantin A.; Delbaere, Stephanie; Fedorova, Olga A.; Tetrahedron; vol. 68; 38; (2012); p. 7873 – 7883;,
Chiral Catalysts
Chiral catalysts – SlideShare

The chiral-catalyst compound, cas is 14098-24-9 name is Benzo-18-crown 6-Ether, mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

A mixture of chloroform (50 ml) and acetic acid (50 ml) were charged in 250 ml round bottom flask. The monobenzo 18-crown-6 ether was added in to the mixture and stirred well. Afterword 8.5 ml nitric acid (70%) slowly dropwise added over a period of 30 min and stirring was continued at RT for additional 24 hr. Then the mixture was neutralized with aqueous Na2CO3 and the reaction product in to aqueous layer extract with chloroform (70 ml x 3). The combined chloroform layer dried by Na2SO4 and evaporated on rotary evaporator observed a yellow crude solid. Crude solid was recrystallized in ethanol to furnish a pure nitro product. Yield: 77%; m.p. 69-71C (Lit.70-72C).

With the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

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Article; Patil, Dayanand R.; Chandam, Dattatraya R.; Mulik, Abhijeet G.; Jagdale, Suryabala D.; Patil, Prasad P.; Deshmukh, Madhukar B.; Synthetic Communications; vol. 45; 16; (2015); p. 1902 – 1911;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14098-24-9,Benzo-18-crown 6-Ether,as a common compound, the synthetic route is as follows.

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product., 14098-24-9

14098-24-9 Benzo-18-crown 6-Ether 585779, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,14098-24-9

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product.

With the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,14098-24-9

A mixture of 3a (1 mmol) and benzo[18]krown-6 (312 mg, 1 mmol) in trifluoroacetic acid (2 mL) was kept for 24 h at room temperature. The solvent was removed under reduced pressure. The residue was diluted in aqueous ethanol and neutralized with a triethylamine to pH = 7. The obtained solution was stayed for 3 days in an open vessel. The precipitated product was separated by filtration and washed three times with water (3 * 5 mL) and dried in vacuo at 120 C. Yellow crystals; Yield 50%; Mp 240-242 C. 1H NMR (400 MHz, DMSO-d6) delta 8.66 (s, 1H), 8.48 (dd, J = 8.0, 2.0 Hz, 1H), 8.23 (d, J = 2.0 Hz, 1H), 7.22 (d, J = 8.0 Hz, 1H), 4.24-4.20 (m, 4H), 3.86-3.80 (m, 4H), 3.67-3.62 (m, 4H), 3.62-3.60 (m, 4H), 3.55 (s, 4H). 13C NMR (101 MHz, DMSO-d6+CCl4) delta 154.58, 154.04, 153.99, 152.08, 148.14, 143.60, 129.32, 126.68, 124.18, 112.45, 69.91, 69.77, 69.69, 68.57, 68.49, 68.22. Anal. Calcd. For C21H25N7O6: C, 53.50; H,5.34; N, 20.80. Found: C, 53.42; H, 5.47; N, 20.73.

With the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

Reference£º
Article; Gorbunov, Evgeny B.; Rusinov, Gennady L.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.; Charushin, Valery N.; Chupakhin, Oleg N.; Tetrahedron Letters; vol. 57; 21; (2016); p. 2303 – 2305;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,Benzo-18-crown 6-Ether,14098-24-9,Molecular formula: C16H24O6,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO415,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

For example, the co-crystal compound of the present invention can be prepared by an anti-solvent method, and the specific implementation is described below. With reference to FIG. 2 for a schematic view of preparing a co-crystal compound of the present invention, the same mole of ammonium nitrate (NH4NO3) and benzo-18-crown-6-ether (C16H24O6) are prepared and added into a glass reactor 200. In this preferred embodiment, the quantities of both ammonium nitrate and benzo-18-crown-6-ether are equal to 0.048 mole, and then a 25 ml pipette 210 is used to titrate approximately 31 ml of methanol (MeOH) in the glass reactor 200. A water bath takes place in the glass reactor 200 in a water tank at 25 C., and a blender 220 is provided for blending at 250 rpm for two hours., and finally the 25 ml pipette 210 is used for titrate methyl tertiary butyl ether into the glass reactor 200 slowly. Now, the solution in the glass reactor 200 becomes turbid gradually, and then we can wait for the formation of the co-crystal compound of the present invention.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Patent; NATIONAL CENTRAL UNIVERSITY; Tu, Lee; Chen, Jeng-Wei; US2013/102797; (2013); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO311,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

General procedure: A modification of the previously reported procedure23 was used. Commercially available Eaton’s reagent (ca. 8 ml that corresponds to 6.28 mmol of phosphorus(V) oxide) and acetic acid (0.20 ml, 3.45 mmol) were mixed at room temperature. Then naphtho-15-crown-5 ether (1 g, 3.14 mmol) was added. The reaction mixture was stirred at room temperature for ca. 6 h and then poured into water. The suspension was extracted with dichloromethane and the combined organic phases were washed with water. Removal of the dried (MgSO4) solvent gave a dark brown oil, which upon repeated extractions with hot heptane, afforded the product as an off-white solid (1.02 g, 90%), mp 126-129 C.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Article; Paramonov, Sergey V.; Lokshin, Vladimir; Smolentsev, Artem B.; Glebov, Evgeni M.; Korolev, Valeri V.; Basok, Stepan S.; Lysenko, Konstantin A.; Delbaere, Stephanie; Fedorova, Olga A.; Tetrahedron; vol. 68; 38; (2012); p. 7873 – 7883;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO35,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

Concentrated nitric acid (0.25 ml) was added to a stirring solution of benzo-18-crown-6 (12) (0.25 g, 0.81 mmol) in dichloromethane (15 ml). The solution was allowed to stir at room temperature for 24 hours. The organic layer was washed with water (3 x 30 ml), dried over sodium sulfate, filtered and the solvent removed under reduced pressure. The isolated oily product solidified upon standing to give 0.28 g of (13) as a yellow crystalline solid (0.78 mmol, 96 % yield). 1H n. m. r. of the crude indicated the presence of product and also dichloromethane. The product was allowed to dry for another 24 hours before its employment in subsequent reactions. Melting point: 82-83 C (Literature mp: 80-81 C)31. Decompostion at: 312 C. 1H n. m. r. (300 MHz, CDCl3): delta 7.88 (dd, 1H, J 8.9 Hz, 2.6 Hz, Ar-H); 7.74 (d, 1 H, J 2.6 Hz, Ar-H); 6.89 (d, 1 H, J 8.9 Hz, Ar-H); 4.24 (m, 4H, OCH2); 3.95 (m, 4H, OCH2); 3.77 (m, 4H, OCH2); 3.72 (m, 4H, OCH2); 3.68 (s, 4H, OCH2). 13C n. m. r. (75 MHz, CDCl3): delta 154.3, (C4); 148.4, (C2); 141.3, (C1); 117.9, (C5); 111.2, (C6); 108.1, (C3); 70.99, (OCH2); 70.98, (OCH2); 70.8, (OCH2); 70.7, (OCH2); 70.60, (OCH2); 70. 57, (OCH2); 69.23, (OCH2); 69.17, (OCH2); 69.1, (OCH2). IR (Nujol): 1587, m; 1520, s; 1464, s; 1338, s; 1276, s; 1128, s; 864, w. Mass spectrum (ESI,+ve): m/z 358.1 [M]+; 381.1 [M + Na]+.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Patent; Monash University; WO2003/99762; (2003); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare