Tag: M.W:300-400

1,3-Dimesityl-1H-imidazol-3-ium chloride, cas is 141556-45-8, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,141556-45-8

General procedure: Under an N2 atmosphere, the mixture of imidazolium salts 1 (1.1 mmol), benzoxazole or benzothiazole (2.0 mmol), PdCl2 (1.0 mmol) and K2CO3 (1.1 mmol) was stirred in anhydrous THF (10 mL) under reflux for 16 h. After cooling, filtration and evaporation,the residue was purified by preparative TLC on silica gelplates eluting with CH2Cl2 to afford the corresponding N-heterocyclic carbene-palladium(II) complexes 3a-d.

As the rapid development of chemical substances, we look forward to future research findings about 141556-45-8

Reference£º
Article; Wang, Tao; Xie, Huanping; Liu, Lantao; Zhao, Wen-Xian; Journal of Organometallic Chemistry; vol. 804; (2016); p. 73 – 79;,
Chiral Catalysts
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Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,14098-24-9

General procedure: 4.2.1. Method A. molecular clip 2 was obtained in 50% yield as described6b Method B. A mixture of bisether 8 (1 g, 2.65 mmol) and corresponding benzocrown ether (5.42 mmol) in PPA (30 g) was stirred vigorously at 80-85 for 30 min. A deep purple color was formed in 5 min. To the cooled reaction mixture was added water (150 mL) and product was extracted with CHCl3 (3¡Á50 mL). The organic layer was washed with water until neutral (?3¡Á50 mL) and subjected to azeotropic drying. The solvent was removed at reduced pressure and the residue was dissolved in a mixture of CHCl3/MeOH (50:1, 100 mL) and filtered through SiO2 (~30 mL). The solvent was removed at reduced pressure and the crude product was purified as described below. Method C. The procedure is similar to Method B, with exception that tetraol 9 (1.1 g, 2.65 mmol) was used instead bisether 8. Method D. A suspension of NaH (0.288 g, 12 mmol) in DMSO (26 mL) was heated with stirring at 70 for 30 min. The resulting mixture was cooled to room temperature and a solution of 11 (0.78 g, 2.65 mmol) in DMSO (40 mL) was added. Stirring was continued for 20 min and then solution of 10 (5.92 g, 5.83 mmol) in DMSO (40 mL) was added dropwise over 5 min and the resulting mixture was stirred at room temperature for 24 h. The mixture was poured into ice water (400 mL) and acidified with HCl to pH~2. The resulting solid was filtered off, washed with water (3¡Á50 mL). The crude product was purified as described below.

As the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

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Article; Bogaschenko, Tatiana Yu.; Lyapunov, Alexander Yu.; Kikot’, Leonid S.; Mazepa, Alexander V.; Botoshansky, Mark M.; Fonari, Marina S.; Kirichenko, Tatiana I.; Tetrahedron; vol. 68; 24; (2012); p. 4757 – 4764;,
Chiral Catalysts
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141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 0.340 g (1.00 mmol) of 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride was deprotonated by the addition of n-BuLi (1.00 mmol) in THF at -40C. The reaction mixture was allowed to stir for 30 min after which 0.390 g dimanganese decacarbonyl (1.00 mmol) was added. The reaction mixture turned a deep orange colour after the introduction of the metal complex and the reaction mixture was allowed to slowly warm up to room temperature. The solvent was removed in vacuo and purified via silica gel chromatography by eluting first with hexane and secondly with a hexane-DCM 1:1 mixture.

141556-45-8, As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.

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Article; Fraser, Roan; van Sittert, Cornelia G.C.E.; van Rooyen, Petrus H.; Landman, Marile; Journal of Organometallic Chemistry; vol. 835; (2017); p. 60 – 69;,
Chiral Catalysts
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1,3-Dimesityl-1H-imidazol-3-ium chloride, cas is 141556-45-8, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,141556-45-8

To anhydrous 1,4-dioxane (20 mL), [Pd(acac)2] (1 g, 3.3 mmol,1 equiv) and IMes*HCl (1.43 g, 3.7 mmol, 1.1 equiv) were added. The mixture was refluxed for 24 h. After the reaction, solvent was evaporated under vacuum. Diethyl ether was then added and stirred until no more solid was dissolved. The solution was filtered and diethyl ether was removed under vacuum. Yellow powder was washed with n-pentane and dried under vacuum. Yellow solids, yield:85%, 1H NMR (399.78 MHz, CDCl3) delta 7.08-6.94 (br,6H), 5.1 (s, 1H), 2.47-2.02 (br, 18H), 1.84-1.73 (6H), 13CNMR (100.53 MHz, CDCl3) delta 187.21, 183.16, 153.93,139.29, 137.60, 136.35, 135.01, 129.76, 128.90, 123.8,122.57, 99.68, 27.17, 25.61, 21.29, 18.93, 17.85.Synthesis of (IMes)Pd(tmhd)Cl. Yellow solids, yield:76%, 1H NMR (399.78 MHz, CDCl3) delta 7.09-6.96 (6H),5.50 (s, 1H), 2.40-2.31 (12H), 2.21-2.16 (6H), 1.04-0.95(18H), 13C NMR (100.53 MHz, CDCl3) delta 139.08, 136.64,135.40, 130.00, 128.74, 124.04, 90.65, 41.15-40.64, 29.07,28.51, 21.25, 18.99.

As the rapid development of chemical substances, we look forward to future research findings about 141556-45-8

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Article; Lee, Dong Jin; Kim, Myungwoong; Kim, Chan Kyung; Lee, Ik Mo; Bulletin of the Korean Chemical Society; vol. 40; 7; (2019); p. 710 – 718;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14098-24-9,Benzo-18-crown 6-Ether,as a common compound, the synthetic route is as follows.

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product., 14098-24-9

14098-24-9 Benzo-18-crown 6-Ether 585779, achiral-catalyst compound, is more and more widely used in various fields.

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Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of the dimeric Ni(II)-complex in THF (20 mL) wasadded the respective imidazolium chloride (2 equiv.) and KOtBu(2.3 equiv.) or NaHMDS (2.3 equiv.). The reaction mixture washeated to 60 C for 2 h and then left at room temperature overnight.The solvent was removed under reduced pressure and the residuewas extracted into CH2Cl2. This CH2Cl2 solutionwas passed througha short column of alumina. The eluting orange-brown solution wassubsequently evaporated to dryness. Diffusion of cyclohexane intoa THF solution afforded orange-brown crystals after several days.Samples for elemental analysis were further recrystallised fromMeOH., 141556-45-8

The synthetic route of 141556-45-8 has been constantly updated, and we look forward to future research findings.

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Article; Clauberg, Maximilian H.; Schmidt, Darya; Rust, Joerg; Lehmann, Christian W.; Arefyeva, Natalia; Wickleder, Mathias; Mohr, Fabian; Journal of Organometallic Chemistry; vol. 881; (2019); p. 45 – 50;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14098-24-9,Benzo-18-crown 6-Ether,as a common compound, the synthetic route is as follows.

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product., 14098-24-9

The synthetic route of 14098-24-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

173035-10-4, 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

RuCl2(?CHPh)(PCy3)s (phenylmethylene-bis(tricyclohexylphosphine) ruthenium dichloride, ?catalyst (I)?) (6.00 g, 7.29 mmol, 1.0 eq.), IMesH2.HCl salt prepared above (2 eq.), and potassium t-butoxide (2 eq.) were placed in a Schlenk flask. 60 mL of anhydrous degassed hexanes (Aldrich SureSeal bottle) were added. A vacuum was applied to further degas the reaction mixture, which was then heated to 60 C. for 24 hours. The suspension changed color from purple to orange-brown over the reaction time. After approximately 24 hr, the mixture was cooled to room temperature, and an excess of 1:1 isopropanol:water (180 mL) was added. The mixture was stirred rapidly in air for 30 min., then filtered using a medium porosity frit, and washed with isopropanol-water (3¡Á100 mL) and hexanes (3¡Á100 mL). The solids were dried in in vacuo, and the yield was approximately 75%. 1H NMR (CD2Cl2, 400 MHz) delta 19.16 (s, 1H), 7.37-7.05 (m, 9H), 3.88 (s, 4H), 2.56-0.15 (m, 51H); 31P NMR (CD2Cl2, 161.9 MHz) delta 31.41; HRMS (FAB) C45H65Cl2N2PRu [M+] 848.3306, found 848.3286., 173035-10-4

173035-10-4 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride 2734917, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; Grubbs, Robert H.; Chatterjee, Arnab K.; Choi, Tae-Lim; Goldberg, Steven D.; Love, Jennifer A.; Morgan, John P.; Sanders, Daniel P.; Scholl, Matthias; Toste, F. Dean; Trnka, Tina M.; (27 pag.)US9403854; (2016); B2;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

In analogy to S. P. Nolan, Organometallics 1999, 18, 5416-5419, a suspension of 1.55 g (4.33 mmol) of 1,3-bis(2,4,6-trimethylphenyl)-imidazolium chloride (commercially available from Strem Chemicals Inc., D-77672 Kehl) and 2.70 ml (4.59 mmol) of potassium tert.-pentylate (1.7 M in toluene) was suspended in 20 ml hexane and heated at 50 C. for 10 min. 2.00 g (2.17 mmol) of [RuCl2(Pcy3)2(3-phenyl-indenylidene)] was added and the resulting red suspension stirred at 50 C. for 15 h. The reaction mixture was allowed to cool to r.t., the formed brown crystals were filtered off and washed with 40 ml pentane. The crystals were dissolved in 30 ml dichloromethane. 30 ml water was added and the organic layer was separated and dried over Na2SO4. The orange solution was evaporated to dryness and the isolated red crystals washed with 30 ml pentane and dried under vacuum to yield 2.05 g (81% yield) of the title compound. MS: 946.3 (M+). 31P-NMR (121 MHz, C6D6): 27.4 ppm. 1H-NMR (300 MHz, C6D6): 1.00-1.40 (m, 18H); 1.47-1.68 (m, 6H); 1.70-1.84 (m, 3H); 1.80 (s, 3H); 1.85-1.95 (m, 3H); 2.04 (s, 3H); 2.20 (s, 3H); 2.24 (s, 3H); 2.45-2.60 (m, 3H); 2.65 (s, 3H); 2.67 (s, 3H); 6.03 (s, 1H); 6.16 (s, 2H); 6.47 (s, 1H); 6.95 (s, 2H); 7.10-7.37 (m, 6H); 7.85 (s, 1H); 7.87-7.93 (m, 2H); 9.12 (d, 1H, J=6.8 Hz). Anal. calcd. for C54H67N2Cl2PRu: C, 68.48; H, 7.13; N, 2.96; Cl, 7.49. Found: C, 68.71; H, 7.11; N, 3.77; Cl, 7.37., 141556-45-8

As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.

Reference£º
Patent; Puentener, Kurt; Scalone, Michelangelo; US2006/241156; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare