Tag: M.W:400-500

As a common heterocyclic compound, it belong chiral-catalyst compound,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,250285-32-6,Molecular formula: C27H37ClN2,mainly used in chemical industry, its synthesis route is as follows.,250285-32-6

IPr-HCI (82.04 mg, 0.193 mmol), [Pd(allyl)(M-CI)]2 (35.3 mg, 0.0965 mmol), a magnetic stir bar and acetone (0.8 mL) were charged to a vial . The mixture was stirred at 60 C for 1 h. Then the solvent was removed and dried under vacuum. The product was obtained as a yellow powder in a 99% (117 mg). XH NMR (400 MHz, CDCIs): delta (ppm) = 9.16 (s, 1H), 8.28 (d, J = 1.62 Hz, 2H), 7.54-7.50 (m, 2H), 7.32 (d, J = 7.17 Hz, 4H), 5.16-5.10 (m, 1H), 3.76 (s, 2H), 2.67 (d, J = 11.57 Hz, 2H), 2.48-2.44 (m, 4H), 1.27 (d, J = 6.79 Hz, 12H), 1.20 (d, J = 7.20 Hz, 12H).13C {XH} NMR (100 MHz, CDCIs): delta (ppm) = 5144.9 (C), 136.8 (CH), 131.8 (C), 129.7 (C), 127.3 (CH), 124.4 (CH), 108.9 (C), 60.3 (CH), 28.8 (CHs), 24.4 (CHs), 23.8 (CHs). Elemental analysis: Expected : C 59.07, H 7.27 N 4.59, Found : C 58.90 H 7.17 N 4.57.

With the synthetic route has been constantly updated, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,belong chiral-catalyst compound

Reference£º
Patent; UMICORE AG & CO. KG; NOLAN, Steven P.; (47 pag.)WO2018/115029; (2018); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 250285-32-6, its synthesis route is as follows.,250285-32-6

A vial was charged with [Au(SMe2)Cl] (53mg, 190mumol, 1.06 equiv.), IPr.HCl (76mg, 179mumol, 1 equiv.) and KOtBu (31mg, 277mumol, 1.5 equiv.) in THF (0.5mL), under air. The mixture was stirred for 2h at room temperature. KOtBu (62mg, 553mumol, 3 equiv.) was then added followed by toluene (0.5mL). After 3h at room temperature, the crude mixture was then filtered through Celite and washed with additional THF. Water (0.1mL) was added to the solution and the solution was stirred for an additional 15min. THF was then removed under vacuum. More water was added to the white, cloudy suspension and the product was vigorously stirred for a few minutes. It was left to settle for 10min, collected using a Buchner funnel and washed with hexane. It was then dried under vacuum for several days to produce a white microcrystalline solid.

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Article; Nahra, Fady; Patrick, Scott R.; Collado, Alba; Nolan, Steven P.; Polyhedron; vol. 84; (2014); p. 59 – 62;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,250285-32-6

IPr-HCI (82.04 mg, 0.193 mmol), [Pd(cin)(M-CI)]2 (50.0 mg, 0.096 mmol), a magnetic stir bar and acetone (0.8 mL) were charged into a vial . The mixture was stirred at 60 C for 1 h . The solvent was removed and the product was dried under vacuum . The product was obtained as a dark orange powder in a 99% ( 132 mg) yield . Single crystals were grown by vapour diffusion of hex- ane into a solution of the complex in DCM . XH IMMR (400 MHz, CDCh) : delta (ppm) = 9.19 (s, 1 H), 8.32 (d, J = 1.60 Hz, 2H), 7.56-7.52 (m, 2H), 7.46 (d, J = 7.44 Hz, 2H), 7.33 (d, J = 7.75 Hz, 4H), 7.21 (m, 3H), 5.66 (s, 1 H), 4.46 (s, 1 H), 3.83 (s, 1 H), 2.90 (s, 1 H), 2.48- 2.41 (m, 4H), 1.27 (d, J = 6.81 Hz, 12H), 1.19 (d, J = 6.76 Hz, 12H) . 13C {XH } NMR (100 MHz, CDCh): delta (ppm) = delta 144.9 (C), 136.7 (CH), 131.8 (C), 129.7 (C), 128.4 (CH), 127.7 (CH), 127.5 (CH), 124.5 (CH), 105.0 (C), 28.8 (CHs), 24.4 (CHs), 23.7 (CHs) . Elemental analysis: Expected : C 63.02, H 7.05 N 4.08 Found : C 62.92 H 7.14 N 4.15

250285-32-6 is used more and more widely, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Patent; UMICORE AG & CO. KG; NOLAN, Steven P.; (47 pag.)WO2018/115029; (2018); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,250285-32-6

To anhydrous1,4-dioxane (20 mL), [Pd(acac)2] 1 g (3.3 mmol,1 equiv) and IPrHCl 1.56 g (3.7 mmol, 1.1 equiv) were added. The mixture was refluxed for 24 h. After reaction,solvent was evaporated under vacuum. Then, dichloromethane was added and stirred until no more soliddissolved. The solution was filtered and dichloromethane was removed under vacuum. Yellow powder obtained was washed with diethyl ether and dried under vacuum. Yellow solids, yield: 85%, 1H NMR (399.78 MHz, CDCl3 delta 7.49(t, 2H), 7.32 (m, 4H), 7.10 (s, 2H), 5.10 (s, 1H), 2.94 (td,4H), 1.81 (d, 6H), 132 (d, 12H), 1.08 (12H), 13C NMR(100.53 MHz, CDCl3) delta 186.70, 183.61, 155.98, 146.61,135.05, 130.42, 125.30, 124.20, 99.46, 28.54, 27.13,26.36, 23.07.

250285-32-6 is used more and more widely, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Article; Lee, Dong Jin; Kim, Myungwoong; Kim, Chan Kyung; Lee, Ik Mo; Bulletin of the Korean Chemical Society; vol. 40; 7; (2019); p. 710 – 718;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,250285-32-6

General procedure: A mixture of pyrazine ligand 1 or 2 (1mmol), Li2PdCl4 (1mmol) and NaOAc (1mmol) in 20mL of dry methanol was stirred for 24hat rt. The yellow solids (yield: 92%) were collected by filtration and washed several times with methanol, which can be assigned to be palladacyclic dimers. Then, a Schlenk tube was charged with the above chloride-bridged palladacyclic dimers (0.5mmol), the corresponding imidazolium salt (1.25mmol) and tBuOK (2.5mmol) under nitrogen. Dry THF was added by a cannula and stirred at room temperature for 3h. The product was separated by passing through a short silica gel column with CH2Cl2 as eluent, the third band was collected and afforded the corresponding carbene adducts 3-10 as yellow solids. The characterization data for 3: Yield: 78%.

250285-32-6 is used more and more widely, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Article; Xu, Chen; Wang, Zhi-Qiang; Fu, Wei-Jun; Ji, Bao-Ming; Yuan, Xiao-Er; Han, Xin; Xiao, Zhi-Qiang; Hao, Xin-Qi; Song, Mao-Ping; Journal of Organometallic Chemistry; vol. 777; (2015); p. 1 – 5;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 250285-32-6, its synthesis route is as follows.,250285-32-6

Finely powdered PdCl2 (177 mg, 1.00 mmol) was suspended in CH3CN (5 mL), and N- benzyldimethylamine (160 muL, 143 mg, 1.05 mmol) were added. The solution was heated to 8O0C with stirring a until clear, orange solution was formed (approx. 20 min). Finely powdered K2CO3 (691 mg, 5.00 mmol) was added and the stirring was continued until palladacycle formation was complete, as indicated by the formation of a canary yellow solution (5-10 min) . IPr-HCl (467 mg, 1.10 mmol) was added and the mixture was stirred at 8O0C over 18h. The reaction mixture was filtered and evaporated. The resulting product was purified by column chromatography. Upon application of the product to a pad of silica gel (2.5 x 8 cm) pre-equilibrated with CH2Cl2, CH2Cl2 (100 mL) was used to elute impurities. The pure NHC-palladacycles were eluted with CH2Cl2-ethylacetate (3:1, vol/vol, 150 mL), and the solvents were evaporated. The products were triturated with hexanes (25 mL). After drying in high vacuum, IPr- Pd(dmba)Cl (543 mg, 82%) was obtained as beige solid. 1H NMR (CDCl3, 400 MHz) delta: 7.40 (t, J= 7.6 Hz, 2H), 7.30 (d, J= 7.6 Hz, 2H); 7.21 (s, 2H), 6.82-6.70 (m, 3H), 6.53 (d, J = 7.6 Hz, IH), 3.46 (s, 2H), 3.37 (m, 2H), 3.15 (m, 2H)5 2.39 (s, 6H)5 1.49 (d, J= 6.8 Hz, 6H), 1.18 (d, J= 6.8 Hz, 6H), 1.02 (d, J= 6.8 Hz, 6H), 0.81 (d, J= 6.4 Hz, 6H). 13C NMR (CDCl3, 100 MHz) delta: 177.5, 150.5, 147.8, 147.8, 144.7, 136.2, 136.1, 129.7, 125.4, 124.6, 124.0, 123.8, 122.6, 121.5, 72.6, 49.8, 29.0, 28.3, 26.4, 26.2, 23.2, 23.2. Anal, calcd for C36H48ClN3Pd (665.67): C, 65.05; H, 7.28; N, 6.32. Found: C, 65.14; H, 7.41; N, 6.53.

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; WO2008/156451; (2008); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 250285-32-6, its synthesis route is as follows.,250285-32-6

Under the protection of nitrogen, to the reaction tube is sequentially added imidazole salt IPr¡¤HCl (1.1mmol), palladium chloride (1.0mmol), potassium carbonate (2.2mmol), tetrahydrofuran (5.0 ml) and isoquinoline (2.0mmol). The mixture is placed in the oil bath heated reaction (80 C) 12 hours. Stopping the reaction, cooling to room temperature, pressure reducing turns on lathe does solvent, rapid column chromatography separation to obtain a yellow solid product 0.1148g, yield 83%.

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Patent; Wenzhou University; Shao Lixiong; Lu Jianmei; Liu Feng; (23 pag.)CN106892945; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO284,mainly used in chemical industry, its synthesis route is as follows.,250285-32-6

Under the protection of nitrogen, to the reaction tube is sequentially added imidazole salt IPr¡¤HCl (1.1mmol), palladium chloride (1.0mmol), potassium carbonate (2.2mmol), tetrahydrofuran (5.0 ml) and isoquinoline (2.0mmol). The mixture is placed in the oil bath heated reaction (80 C) 12 hours. Stopping the reaction, cooling to room temperature, pressure reducing turns on lathe does solvent, rapid column chromatography separation to obtain a yellow solid product 0.0537g, yield 39%.

With the synthetic route has been constantly updated, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,belong chiral-catalyst compound

Reference£º
Patent; Wenzhou University; Shao Lixiong; Lu Jianmei; Liu Feng; (23 pag.)CN106892945; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

250285-32-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6,the chiral-catalyst compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride(0.425 g, 1.0 mmol), [Cp*IrCl2]2 (0.398 g, 0.5 mmol), and K2CO3(0.484 g, 3.5 mmol) in anhyd THF (8 mL)-CH2Cl2 (2 mL) wasstirred at 24 C for 10 h under N2. The resulting suspension wasstirred at 60 C for 24 h under N2, then concentrated to dryness. Afterthe addition of CH2Cl2 (10 mL) to the residue, the resulting suspensionwas filtered through Celite. The filtrate was concentrated todryness to give the iridium complex 2 as a brownish orange solid(0.748 g, 0.963 mmol, 96%).IR (ATR, ZnSe): 1659 cm-1 (CO2).1H NMR (500 MHz, CD2Cl2): delta = 7.43 (t, J = 8.0 Hz, 2 H), 7.33 (d,J = 8.0 Hz, 4 H), 7.09 (s, 2 H), 2.99-2.94 (m, 4 H), 1.45 (d, J = 7.0Hz, 12 H), 1.21 (s, 15 H), 1.06 (d, J = 6.0 Hz, 12 H).13C{1H} NMR (126 MHz, CD2Cl2): delta = 168.1, 165.9, 138.1, 130.1,126.4, 124.2, 87.2, 29.0, 27.2, 23.5, 9.4.Anal. Calcd for C38H51IrN2O3¡¤H2O: C, 57.48; H, 6.73; N, 3.53.Found: C, 57.40; H, 6.54; N, 3.57.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 250285-32-6

Reference£º
Article; Yamada, Yoichim. A.; Ohta, Hidetoshi; Yuyama, Yoshinari; Uozumi, Yasuhiro; Synthesis; vol. 45; 15; (2013); p. 2093 – 2100;,
Chiral Catalysts
Chiral catalysts – SlideShare

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a glove box, a Schlenk flask equipped with a magnetic bar is loaded with the imidazolium salt IPr EtaC1 (2.96 g, 7 mmol), Pd(acac), (1.53 g, 5 mmol) and dry dioxane (100 mL). The flask was taken outside the glove box and placed in an oil bath at 100 C over a magnetic stirrer for 6 hours. After that time, the solution looked clear with no solid remaining. The solvent was evaporated in vacuo and diethyl ether was added until no more solid was dissolved. The solution is filtered and the solid washed with diethyl ether (2 x 10 mL). The solvent was evaporated in vacuo to yield 2.99 g (95 %) of the desired compound as a yellow powder.1H NMR (delta, 400 MHz, CDCl3): 7.51 (t, / = 7.8 Hz, 2H), 7.35 (d, / = 7.8 Hz, 4H), 7.12 (s, 2H), 5.12 (s, IH), 2.95 (q, / = 6.4 Hz, 4H), 1.84 (s, 3H), 1.82 (s, 3H), 1.34 (d, / = 6.4 Hz, 12H), 1.10 (d, / = 6.4 Hz, 12H). EPO 13C NMR (delta, 100 MHz, CDCl3): 187.1, 184.1, 156.4, 147.0, 135.5, 134.8, 130.9, 125.7, 124.7, 124.6, 99.9, 29.1, 30.0, 27.6, 26.8, 23.7, 23.5.Anal. Calcd. for C32H43ClN2O2Pd (MW 629.57): C, 61.05; H, 6.88; N, 4.45. Found: C, 60.78; H, 7.15; N: 4.29.

250285-32-6, The synthetic route of 250285-32-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROMERUS LLC; WO2006/128097; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare