Tag: M.W:400-500

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO462,mainly used in chemical industry, its synthesis route is as follows.,250285-32-6

Under inert atmosphere, 1,3-bis-(2,6-diisopropylphenyl)imidazolium chloride (1.59 g,3.74 mmol, 1.00 equiv.) was dissolved in dichloromethane (170 mL) and silver(I) oxide (0.478 g,2.06 mmol, 1.10 equiv.) was added. The mixture was stirred at room temperature for 25 h and then iodine (1.04 g, 4.10 mmol, 1.10 equiv.) in dichloromethane (50 mL) was added slowly andstirred overnight. The mixture was deactivated by NaS2O3, the organic layer was separated anddried over MgSO4. After removal of the solvent, the residue was dissolved in methanol and asolution of NaBPh4 (1.51 g, 4.40 mmol, 1.18 equiv.) in methanol (15 mL) was added. Theforming solid was filtrated off and dried in vacuum to afford the desired product as a colorlesssolid (2.25 g, 2.69 mmol, 72 %).

With the synthetic route has been constantly updated, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,belong chiral-catalyst compound

Reference£º
Article; Von Der Heiden, Daniel; Detmar, Eric; Kuchta, Robert; Breugst, Martin; Synlett; vol. 29; 10; (2018); p. 1307 – 1313;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO66,mainly used in chemical industry, its synthesis route is as follows., Author tianliPosted on 02/11/2020Categories 250285-32-6, chiral-catalystTags M.W:400-500

As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, and cas is 250285-32-6, its synthesis route is as follows.,250285-32-6

General procedure: A 20 mL vial was charged with the NHC¡¤HCl (300 mg, 1 equiv.) and the zinc salt (1 equiv.). Tetrahydrofuran (5 mL) was added, the vial was sealed with a screw-cap and the reaction was stirred at 60C for two hours. The mixture was allowed to reach room temperature and the solvent was removed under reduced pressure toafford the desired product.

With the complex challenges of chemical substances, we look forward to future research findings about 250285-32-6,belong chiral-catalyst compound

Reference£º
Article; Santoro, Orlando; Nahra, Fady; Cordes, David B.; Slawin, Alexandra M.Z.; Nolan, Steven P.; Cazin, Catherine S.J.; Journal of Molecular Catalysis A: Chemical; vol. 423; (2016); p. 85 – 91;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO114,mainly used in chemical industry, its synthesis route is as follows.,250285-32-6

Under inert atmosphere, 1,3-bis-(2,6-diisopropylphenyl)imidazolium chloride (1.03 g,1.86 mmol, 1.00 equiv.) was dissolved in dichloromethane/acetonitrile mixture (40 mL, 1:1 v/v)and silver(I) oxide (366 mg, 1.58 mmol, 0.85 equiv.) was added. The mixture was stirred at roomtemperature for 2 d and the solvent was removed in vacuum and the residue was treated withdichloromethane (20 mL) and not soluble material was filtered off. Then, iodine (802 mg,3.16 mmol, 1.70 equiv.) in dichloromethane (20 mL) was added slowly and stirred overnight andthe solvent was removed in vacuum. The crude intermediate, was dissolved in MeOH/H2O(150 mL, 1:2 v/v) and NaOTf (480 mg, 2.79 mmol, 1.50 equiv.) in MeOH/H2O (60 mL, 1:5 v/v)was added. More water (150 mL) was added to complete the precipitation. The solid was filteredoff and was recrystallized from CH2Cl2/MTBE to give C6-OTf (700 mg, 1.05 mmol, 57 %).

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,belong chiral-catalyst compound

Reference£º
Article; Von Der Heiden, Daniel; Detmar, Eric; Kuchta, Robert; Breugst, Martin; Synlett; vol. 29; 10; (2018); p. 1307 – 1313;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 250285-32-6, its synthesis route is as follows.,250285-32-6

Tris [4- (pyridin-4-yl) phenyl] amine compound (47.6 mg, 0.10 mmol)1,3-bis (2,6-diisopropylphenyl) imidazolium chloride (IPr.HCl) (127.5 mg, 0.30 mmol),PdCl2 (53.2 mg, 0.30 mmol)And potassium carbonate (41.5 mg, 0.30 mmol) were added to a 25 mL single neck flask,Tetrahydrofuran (5 mL) was then added,The reaction was stirred at 65 C for 16 h under argon atmosphere.Stop the reaction,Cool to room temperature,concentrate,Thin layer chromatography to give compound I,Yield 57%.

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Patent; Shangqiu Normal University; Wang Tao; Xu Kai; Liu Lantao; Zhao Wenxian; Liu Shuang; Li Feng; Meng Tuanjie; Xie Huanping; (12 pag.)CN105131044; (2017); B;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 250285-32-6, its synthesis route is as follows.,250285-32-6

General procedure: In air, to a Schlenk tube that closed with a screw cap fitted with a septum and was equipped with a magnetic stir bar were added in turn NHC¡¤HCl (1.1 mmol, 468 mg), PdCl2 (1.0 mmol, 177 mg), Cs2CO3 (5 mmol, 1.63 g), and 2-nicotinic acid (1.1 mmol, 136 mg). The tube was then caped with a rubber septum and evacuated and backfilled with argon. This sequence was repeated three times. 1,4-Dioxane (10 mL) was injected through the septum. The mixture was then stirred at a pre-heated oil bath (80 C) for 20 h. The reaction mixture was cooled to room temperature and CH2Cl2 (25 mL) added. After filtration via a short pad of celite, the filtrate was condensed under vacuum and the residue was purified by flash chromatography on silica gel to provide the desired 1 and 2.

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Article; Li, Yan-Jing; Zhang, Jin-Ling; Li, Xiao-Jian; Geng, Yu; Xu, Xiao-Hua; Jin, Zhong; Journal of Organometallic Chemistry; vol. 737; (2013); p. 12 – 20;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,250285-32-6,Molecular formula: C27H37ClN2,mainly used in chemical industry, its synthesis route is as follows.,250285-32-6

taken the imidazole chlorine salt [(R 1 NCHCHNR 1) CH]Cl (0.42 g, 1.0 mmol), ferrous bromide (0.22 g, 1.0 mmol) and sodium bromide (0.33 g, 3.2 mmol), in thf as the solvent, the 60 C reaction under 16 hours. Centrifugal, supernatant fluid transfer, remove precipitation, in the supernatant by adding triphenylphosphine (0.26 g, 1.0 mmol), in 30 C reaction under 6 hours. Vacuum to remove the solvent, hexane washing, drying, in a mixed solvent of toluene and tetrahydrofuran extraction, centrifugal supernatant fluid transfer, after concentrating the serum to obtain a target product, yield 85%.

With the synthetic route has been constantly updated, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,belong chiral-catalyst compound

Reference£º
Patent; Suzhou University; sun, hongmei; li, zhuang; liu, ling; chen, qi; (17 pag.)CN105541922; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under N2 atmosphere, a mixture of imidazolium salts 1 (0.22mmol), PdCl2 (0.2 mmol), K2CO3 (0.44 mmol) and benzo[h]quinoline 2 (0.22 mmol) was stirred in anhydrous THF (2.0 mL) at 50 or 90 C for 18 h. Then the solvent was removed under reduced pressure, and the residue was purified by flash chromatography on silica gel (CH2Cl2) to give complexes 3 as yellow solids. 4.2.1.1 Compound 3a Yellow solid; m.p. 298C (decomposed). 1H NMR (300MHz, CDCl3, TMS) delta 9.44 (dd, J=5.1, 1.2Hz, 1H), 7.98 (dd, J=8.1, 1.5Hz, 1H), 7.56 (d, J=8.7Hz, 1H), 7.45-7.21 (m, 10H), 7.10 (dd, J=7.2, 2.1Hz, 2H), 6.96 (d, J=7.2Hz, 1H), 3.51-3.30 (m, 4H), 1.52 (d, J=6.3Hz, 6H), 1.18 (d, J=6.9Hz, 6H), 1.06 (d, J=6.9Hz, 6H), 0.66 (d, J=6.3Hz, 6H). 13C NMR (125MHz, CDCl3) delta 177.9, 153.9, 153.5, 148.6, 147.8, 145.0, 142.0, 136.3, 135.9, 134.2, 132.8, 129.9, 128.23, 128.18, 125.7, 125.0, 124.2, 123.9, 123.0, 121.7, 120.6, 29.0, 28.4, 26.5, 26.2, 23.2, 23.0. IR (neat) nu 2977, 2927, 2860, 1624, 1593, 1565, 1462, 1394, 1380, 1364, 1330, 1266, 1196, 1182, 1115, 937, 830, 816, 801, 758cm-1. MS (ESI): 672 [M-Cl]+. HRMS (ESI) calcd. for C40H44N3Pd [M-Cl]+: 672.2579; found: 672.2594. Anal. calcd. for C40H44ClN3Pd: C, 67.79%; H, 6.26%; N, 5.93%; found: C, 67.71%; H, 6.26%; N, 5.67%., 250285-32-6

As the paragraph descriping shows that 250285-32-6 is playing an increasingly important role.

Reference£º
Article; Liu, Feng; Hu, Yuan-Yuan; Li, Di; Zhou, Quan; Lu, Jian-Mei; Tetrahedron; vol. 74; 39; (2018); p. 5683 – 5690;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 250285-32-6, its synthesis route is as follows.,250285-32-6

General procedure: conditions 1), NHC.HCl (1.0mmol) was dissolved/suspended in 5mL water. Tollens? reagent was prepared by mixing silver(I) oxide (127mg, 0.548mmol) and concentrated ammonia (0.73mL, 15.3mol/L, 11mmol) until complete dissolution. The reagent was diluted with quantum satis water for a final volume of 5mL. An instantaneous precipitation was observed. After 30minat RT, the white solid was filtered and washed with water. Conditions 2), NHC.HCl (1.0mmol) was dissolved/suspended in 10mL of water or ethanol. Silver(I) oxide (127mg, 0.549mmol) and ammonia (0.65mL, 15.3mol/L, 9.9mmol) were added. After 30-200min at RT, the white solid was isolated by filtration and washed with water (IMes, SIMes) or ethanol (IPr, SIPr).

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Article; Gibard, Clementine; Fauche, Kevin; Guillot, Regis; Jouffret, Laurent; Traikia, Mounir; Gautier, Arnaud; Cisnetti, Federico; Journal of Organometallic Chemistry; vol. 840; (2017); p. 70 – 74;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, cas is 250285-32-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,250285-32-6

taken the imidazole chlorine salt [(R 1 NCHCHNR 1) CH]Cl (0.42 g, 1.0 mmol), ferrous bromide (0.22 g, 1.0 mmol) and sodium bromide (0.33 g, 3.2 mmol), in thf as the solvent, the 60 C reaction under 16 hours. Centrifugal, supernatant fluid transfer, remove precipitation, is added to the supernatant liquid of the three ring hexyl phosphine (0.28 g, 1.0 mmol), in 30 C reaction under 6 hours. Vacuum to remove the solvent, hexane washing, drying, in a mixed solvent of toluene and tetrahydrofuran extraction, centrifugal supernatant fluid transfer, after concentrating the serum to obtain a target product, yield 85%.

With the rapid development of chemical substances, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Reference£º
Patent; Suzhou University; sun, hongmei; li, zhuang; liu, ling; chen, qi; (17 pag.)CN105541922; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare