Application of 21436-03-3. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 21436-03-3, Name is (1S,2S)-Cyclohexane-1,2-diamine. In a document type is Article, introducing its new discovery.
The antimicrobial properties of some copper(ii) and platinum(ii) 1,10-phenanthroline complexes
Copper(ii) (1Cu-21Cu) and previously established experimental anticancer platinum(ii) metallointercalator complexes (1 Pt-16Pt) have been prepared and investigated for their antimicrobial properties. These complexes are of the general structure [M(I L)(AL)]2+ where IL represents functionalised 1,10-phenanthrolines (1IL-10IL), and A L represents 1,2-diaminoethane, 1S,2S- or 1R,2R-diaminocyclohexane. The structures of synthesised complexes were confirmed using a combination of elemental analysis, UV spectrometry, circular dichroism, 1H and [1H-195Pt]-HMQC NMR, X-ray crystallography, and electrospray ionisation mass spectrometry and where appropriate. Crystallisation attempts yielded single crystals of [Cu(4-methyl-1,10-phenanthroline)(1R,2R- diaminocyclohexane)](ClO4)2 (4Cu), [Cu(5,6-dimethyl-1,10-phenanthroline)(1R,2R-diaminocyclohexane)(H 2O)](ClO4)2¡¤1.5H2O (10 Cu) and [Cu(5,6-dimethyl-1,10-phenanthroline)3](ClO 4)2¡¤5,6-dimethyl-1,10-phenanthroline¡¤2H 2O (21Cu). Growth inhibition of liquid cultures of bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), and yeast (Saccharomyces cerevisiae) discerned the most antimicrobially potent metal complexes ?20 muM, as well as that of their intercalating ligands alone. To further investigate their mode of antimicrobial activity, membrane permeabilisation caused by selected complexes was visualised by means of a cell viability kit under fluorescence microscopy.
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Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare