In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles, published in 1998-07-31, which mentions a compound: 22468-26-4, Name is 4-Hydroxypicolinic acid, Molecular C6H5NO3, Category: chiral-catalyst.
This study investigated the structure-activity relationships and kinetic properties of a library of kynurenate analogs as inhibitors of 3H-L-glutamate transport into rat forebrain synaptic vesicles. The lack of inhibitory activity observed with the majority of the monocyclic pyridine derivatives suggested that the second aromatic ring of the quinoline-based compounds played a significant role in binding to the transporter. A total of two kynurenate derivatives, xanthurenate and 7-chlorokynurenate, differing only in the carbocyclic ring substituents, were identified as potent competitive inhibitors, exhibiting Ki values of 0.19 and 0.59 mM, resp. The Km value for L-glutamate was found to be 2.46 mM. Parallel experiments demonstrated that while none of the kynurenate analogs tested effectively inhibited the synaptosomal transport of 3H-D-aspartate, some cross-reactivity was observed with the EAA ionotropic receptors. Mol. modeling studies were carried out with the identified inhibitors and glutamate in an attempt to preliminarily define the pharmacophore of the vesicular transporter. It is hypothesized that the ability of the kynurenate analogs to bind to the transporter may be tied to the capacity of the quinoline carbocyclic ring to mimic the neg. charge of the γ-carboxylate of glutamate. A total of two low energy solution conformers of glutamate were identified that exhibited marked functional group overlap with the most potent inhibitor, xanthurenate. These results help to further refine the pharmacol. specificity of the glutamate binding site on the vesicular transporter and identify a series of inhibitors with which to investigate transporter function.
This literature about this compound(22468-26-4)Category: chiral-catalysthas given us a lot of inspiration, and I hope that the research on this compound(4-Hydroxypicolinic acid) can be further advanced. Maybe we can get more compounds in a similar way.