The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.7181-87-5, Name is 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, molecular formula is C9H11IN2. In a Article£¬once mentioned of 7181-87-5, COA of Formula: C9H11IN2
A chemical-biological evaluation of rhodium(I) n-heterocyclic carbene complexes as prospective anticancer drugs
Rhodium(I) complexes bearing N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological properties of these organometallics. A series of RhI-NHC derivatives with 1,5-cyclooctadiene and CO as secondary ligands were synthesized, characterized, and biologically investigated as prospective antitumor drug candidates. Pronounced antiproliferative effects were noted for all complexes, along with moderate inhibitory activity of thioredoxin reductase (TrxR) and efficient binding to biomolecules (DNA, albumin). Biodistribution studies showed that the presence of albumin lowered the cellular uptake and confirmed the transport of rhodium into the nuclei. Changes in the mitochondrial membrane potential (MMP) were observed as well as DNA fragmentation in wild-type and daunorubicin- or vincristine-resistant Nalm-6 leukemia cells. Overall, these studies indicated that RhI-NHC fragments could be used as partial structures of new antitumor agents, in particular in those drugs designed to address resistant malignant tissues. No resistance to special agents: Rhodium(I) N-heterocyclic carbene (NHC) derivatives with 1,5-cyclooctadiene (COD) and CO as secondary ligands were synthesized, characterized, and biologically investigated as prospective antitumor drug candidates. Pronounced antiproliferative effects were noted for all complexes, along with efficient binding to biomolecules. RhI-NHC fragments could be used as partial structures of new antitumor agents, particularly in drugs designed to address daunorubicin- (DNR) and vincristine (VCR)-resistant malignant tissues (see figure). Copyright
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C9H11IN2, you can also check out more blogs about7181-87-5
Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare