The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate(SMILESS: O=C(C(N1)=C(C=O)C2=C1C=CC(Cl)=C2)OCC,cas:43142-76-3) is researched.Category: chiral-catalyst. The article 《Synthesis and antituberculosis activity of indole-pyridine derived hydrazides, hydrazide-hydrazones, and thiosemicarbazones》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:43142-76-3).
We describe the design, synthesis, and in vitro antimycobacterial activity of a series of novel simple hybrid hydrazides and hydrazide-hydrazones combining indole and pyridine nuclei. The compounds are derivatives of 1-acetylindoxyl or substituted indole-3-carboxaldehydes tethered via a hydrazine group by simple C-N or double C:N bonds with 3- and 4-pyridines, 1-oxide 3- and 4-pyridine carbohydrazides. The most active of the 15 compounds showed MICs values against an INH-sensitive strain of Mycobacterium tuberculosis H37Rv equal to that of INH (0.05-2 μg/mL). Five compounds demonstrated appreciable activity against the INH-resistant M. tuberculosis CN-40 clin. isolate (MICs: 2-5 μg/mL), providing justification for further in vivo studies.
This compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate)Application In Synthesis of Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.