The effect of the change of synthetic route on the product 22468-26-4

After consulting a lot of data, we found that this compound(22468-26-4)Computed Properties of C6H5NO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Computed Properties of C6H5NO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Hydroxypicolinic acid, is researched, Molecular C6H5NO3, CAS is 22468-26-4, about Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs. Author is Xu, Mingshuo; Wang, Yu; Yang, Feipu; Wu, Chunhui; Wang, Zhen; Ye, Bin; Jiang, Xiangrui; Zhao, Qingjie; Li, Jianfeng; Liu, Yongjian; Zhang, Junchi; Tian, Guanghui; He, Yang; Shen, Jingshan; Jiang, Hualiang.

In previous study, a series of benzamides was identified as potent antipsychotic agents. As a continuation of the program to discover antipsychotics, herein we reported the evaluation of a series of pyridinecarboxamide derivatives The most promising compound I not only held good activities on dopamine D2, serotonin 5-HT1A and 5-HT2A receptors, but also exhibited low potency for α1A, H1 and 5-HT2C receptors, indicating a low propensity of side effects like orthostatic hypotension and weight gain. Furthermore, I exhibited more potent antipsychotic-like effect than aripiprazole in behavioral studies. The preliminary results were promising enough for further research around this scaffold.

After consulting a lot of data, we found that this compound(22468-26-4)Computed Properties of C6H5NO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare