The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Hydrolysis of hydrazide compounds by leucine aminopeptidase》. Authors are Wergin, A..The article about the compound:H-Leu-NH2.HClcas:10466-61-2,SMILESS:N[C@@H](CC(C)C)C(N)=O.[H]Cl).Application of 10466-61-2. Through the article, more information about this compound (cas:10466-61-2) is conveyed.
Hydrolysis of leucineamine-HCl (I), leucinehydrazide acetate (II), leucinehydrazinoacetamide acetate (III), and leucinesemicarbazide acetate (IV) by leucine aminopeptidase was optimum at pH 8-9. The spontaneous hydrolysis of the 3 hydrazides at pH 8.7 was relatively slow and could be neglected. The Km and activation energies E at 10-40° and pH 8.7 were [substrate, Km, (M), and E (kcal./mol) given]: I, 3.1 × 10-3, 10.5; II, 3.1 × 10-3, 10.5; III, 2.8 × 10-3, 9.8; IV, 0.72 × 10-3, 8.1.
This compound(H-Leu-NH2.HCl)Application of 10466-61-2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.