The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.21436-03-3, Name is (1S,2S)-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article，once mentioned of 21436-03-3, Application In Synthesis of (1S,2S)-Cyclohexane-1,2-diamine
The monoguanylation of (1S,2S)- and (1R,2R)-cyclohexane-1,2-diamine affords chiral primary amine-guanidines that are used as chiral organocatalysts in the enantioselective Michael addition of aldehydes, particularly alpha,alpha-disubstituted aldehydes, to maleimides. The reaction is carried out in the presence of imidazole, as an additive, in aqueous N,N-dimethylformamide, as the solvent, and affords the corresponding enantioenriched succinimides in high or quantitative yields with enantioselectivities up to 96 % ee. Theoretical calculations (DFT and M06-2X) suggest a different hydrogen-bonding coordination pattern between the maleimide (C=O) and the catalyst (NH groups) is responsible for the enantioinduction switch that is observed when the reaction is carried out using primary amine-guanidines versus primary amine-thioureas as the organocatalysts. Chiral primary amine-guanidines are used as the organocatalyst in an enantioselective Michael addition of aldehydes to maleimides. The obtained enantioenriched succinimides are isolated in high to quantitative yields with ee values up to 96 %. The enantioselectivity is discussed by employing theoretical calculations. Copyright
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of (1S,2S)-Cyclohexane-1,2-diamine, you can also check out more blogs about21436-03-3