Name is (S)-(1-Ethylpyrrolidin-2-yl)methanamine, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 22795-99-9, its synthesis route is as follows.,22795-99-9
0.51 g (1.5 mmol) of compound 1a prepared in Preparation 6 was dissolved in 10 ml of anhydrous toluene, 0.39 ml of thionyl chloride was added,The mixture was heated at 60 ¡ã C under argon for 1 hour and then evaporated to dryness. 10 ml of anhydrous DCM (methylene chloride)(S) -2-aminomethyl-1-ethylpyrrole under ice-water bath, the reaction was stirred at room temperature for 8 hours and then diluted with 50 ml of DCM, washed with saturated aqueous NaHCO 3 solution,Saturated NaCl aqueous solution were washed three times, the organic layer was dried over Na2SO4, filtered and evaporated to give a yellowish oil, medium pressure silica gel column,Mobile phase petroleum ether: ethyl acetate 2: 1, the product fractions were collected and evaporated to dryness to give a yellowish oil 0.6g, yield 88.6percent.
With the complex challenges of chemical substances, we look forward to future research findings about (S)-(1-Ethylpyrrolidin-2-yl)methanamine
Reference£º
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare