The important role of 4488-22-6

With the complex challenges of chemical substances, we look forward to future research findings about [1,1′-Binaphthalene]-2,2′-diamine

Name is [1,1′-Binaphthalene]-2,2′-diamine, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 4488-22-6, its synthesis route is as follows.,4488-22-6

To a solution of BINAM (148 mg, 0. 5 mmol) in THF (anhydrous, 10 mL) was added dropwise 2.5 M n-BuLi in cyclohexane (0.56 mL, 1.4 mmol) at -40oC over 40 min and the reaction mixture was stirred for 1 h. The chlorodiphenylphosphine (440 mg, 1.8 mmol) was added and the reaction was stirred for a further 10 h at -40oC to room temperature. Then, the reaction was quenched with saturated sodium bicarbonate and the mixture was dissolved in little water and extracted with EtOAc (15 mL ¡Á 3). The combined organic extracts were dried (MgSO4)and concentrated. The residue was purified by column chromatography on silica gel using PE-EtOAc as the eluent, to give A-3; yield: 255 mg (67%);

With the complex challenges of chemical substances, we look forward to future research findings about [1,1′-Binaphthalene]-2,2′-diamine

Reference£º
Article; Zhang, Yu; Mao, Mao; Ji, Yi-Gang; Zhu, Jie; Wu, Lei; Tetrahedron Letters; vol. 57; 3; (2016); p. 329 – 332;,
Chiral Catalysts
Chiral catalysts – SlideShare