One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 541-14-0, Name is (S)-3-Hydroxy-4-(trimethylammonio)butanoate, formurla is C7H15NO3. In a document, author is Liu, Dan, introducing its new discovery. COA of Formula: C7H15NO3.
Chiral alpha -aryl glycines play a key role in the preparation of some bioactive products, however, their catalytic asymmetric synthesis is far from being satisfactory. Herein, we report an efficient nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters, affording chiral alpha -aryl glycines in high yields and enantioselectivities (up to 98% ee). The hydrogenation can be conducted on a gram scale with a substrate/catalyst ratio of up to 2000. The obtained chiral N-p-methoxyphenyl alpha -aryl glycine derivatives are not only directly useful chiral secondary amino acid esters but can also be easily deprotected by treatment with cerium ammonium nitrate for further transformations to several widely used molecules including drug intermediates and chiral ligands. Formation of a chiral Ni-H species in hydrogenation is detected by H-1 NMR. Computational results indicate that the stereo selection is determined during the approach of the substrate to the catalyst. Chiral alpha -amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral alpha -aryl glycines in high yields and enantioselectivities.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 541-14-0 help many people in the next few years. COA of Formula: C7H15NO3.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare